Mouse methods and models for studies in hearing.

J Acoust Soc Am

Department of Otolaryngology, Central Institute for the Deaf at Washington University School of Medicine, Washington University School of Medicine, Fay and Carl Simons Center for Hearing and Deafness, Saint Louis, Missouri 63110, USA.

Published: November 2019

AI Article Synopsis

  • Laboratory mice are the primary animal model for hearing research due to their similar cochlear functions and injury patterns found in other mammals.
  • Despite their short lifespan, mice exhibit age-related hearing loss types (presbycusis) comparable to longer-lived mammals, with variations in hair cell loss and strial degeneration.
  • While noise can affect mouse cochleae like in other species, mice show a higher likelihood of permanent changes to hair cells, necessitating preclinical testing of therapies in various animal models, including genetically engineered mice for exploring mechanisms.

Article Abstract

Laboratory mice have become the dominant animal model for hearing research. The mouse cochlea operates according to standard "mammalian" principles, uses the same cochlear cell types, and exhibits the same types of injury as found in other mammals. The typical mouse lifespan is less than 3 years, yet the age-associated pathologies that may be found are quite similar to longer-lived mammals. All Schuknecht's types of presbycusis have been identified in existing mouse lines, some favoring hair cell loss while others favor strial degeneration. Although noise exposure generally affects the mouse cochlea in a manner similar to other mammals, mice appear more prone to permanent alterations to hair cells or the organ of Corti than to hair cell loss. Therapeutic compounds may be applied systemically or locally through the tympanic membrane or onto (or through) the round window membrane. The thinness of the mouse cochlear capsule and annular ligament may promote drug entry from the middle ear, although an extremely active middle ear lining may quickly remove most drugs. Preclinical testing of any therapeutic will always require tests in multiple animal models. Mice constitute one model providing supporting evidence for any therapeutic, while genetically engineered mice can test hypotheses about mechanisms.

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Source
http://dx.doi.org/10.1121/1.5132550DOI Listing

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