Host-Targeted Therapeutics against Multidrug Resistant Intracellular .

is a facultative intracellular pathogen that invades and replicates within many types of human cells. has shown to rapidly overcome traditional antibiotherapy by developing multidrug resistance. Furthermore, intracellular is protected from the last-resort antibiotics-vancomycin, daptomycin, and linezolid-as they are unable to achieve plasma concentrations sufficient for intracellular killing. Therefore, there is an urgent need to develop novel anti-infective therapies against infections. Here, we review the current state of the field and highlight the exploitation of host-directed approaches as a promising strategy going forward.