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Virtual screening: hope, hype, and the fine line in between.
Expert Opin Drug Discov
January 2025
Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, NY, USA.
Introduction: Technological advancements in virtual screening (VS) have rapidly accelerated its application in drug discovery, as reflected by the exponential growth in VS-related publications. However, a significant gap remains between the volume of computational predictions and their experimental validation. This discrepancy has led to a rise in the number of unverified 'claimed' hits which impedes the drug discovery efforts.
View Article and Find Full Text PDFExtending from Adaptation to Resilience Pathways: Perspectives from the Conceptual Framework to Key Insights.
Environ Manage
January 2025
TECNALIA Research & Innovation, Basque Research and Technology Alliance (BRTA), Energy, climate, and urban transition, Parque Tecnológico de Bizkaia, Derio, Spain.
The extent and timescale of climate change impacts remain uncertain, including global temperature increase, sea level rise, and more frequent and intense extreme events. Uncertainties are compounded by cascading effects. Nevertheless, decision-makers must take action.
View Article and Find Full Text PDFCommon and distinct ERP responses to violations of two different types of politeness maxims during sentence comprehension.
Brain Lang
January 2025
School of Psychological and Cognitive Sciences, Peking University, Beijing 100871 China; Beijing Key Laboratory of Behavior and Mental Health and Key Laboratory of Machine Perception (Ministry of Education), Peking University, Beijing 100871 China. Electronic address:
An ERP experiment was conducted to investigate the common and distinct neurocognitive mechanisms underlying the on-line processing of two types of politeness maxims (self-depreciation and other-elevation) and the individual differences during sentence reading. Electroencephalograms were recorded while participants read sentences containing pragmatically appropriate or inappropriate honorific or humble terms. When collapsing all participants' data, inappropriate humble and honorific terms elicited N400 and P600 effects, respectively, which could reflect semantic processing costs and rechecking processes, respectively.
View Article and Find Full Text PDFfor the opportunity to provide a commentary on the article, How Whiteness Shapes Nursing in Canada - What Does the Literature Say? A Rapid Review (Walker et al. 2025). I want to begin by congratulating the authors on completing a rapid review on a very important topic.
View Article and Find Full Text PDFInvolving people with lived experience when setting cerebral palsy research priorities: A scoping review.
Dev Med Child Neurol
January 2025
Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Aim: To describe research priority-setting activities for cerebral palsy (CP) that have been conducted worldwide involving people with lived experience, focusing on participant characteristics, methods employed, identified research priorities, and collaboration as research partners.
Method: The JBI scoping review approach was followed. Six electronic databases and grey literature were searched for all publications up to February 2024.
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