Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca and colleagues describe an inter-orgallenar circuit which involves the lysosomal ceramide production, mitoROS, BAX activation and RyR Ca efflux from the endoplasmic reticulum into the mitochondrion.
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| http://dx.doi.org/10.1016/j.ceca.2019.102113 | DOI Listing |
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