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A pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies.
Sci Rep
January 2025
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
This paper describes the design and initial proof-of-concept of a single pre-clinical transcranial focused ultrasound (FUS) system capable of performing histotripsy (mechanical ablation), hyperthermia, blood-brain barrier opening (BBBO), sonodynamic therapy, or neuromodulation in a murine brain. We have termed it the All-in-One FUS system for murine brain studies, which is the first FUS system of its kind. The 1.
View Article and Find Full Text PDFORACLE: An analytical approach for T, T, proton density, and off-resonance mapping with phase-cycled balanced steady-state free precession.
Magn Reson Med
December 2024
Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Purpose: To develop and validate a novel analytical approach simplifying , , proton density (PD), and off-resonance quantifications from phase-cycled balanced steady-state free precession (bSSFP) data. Additionally, to introduce a method to correct aliasing effects in undersampled bSSFP profiles.
Theory And Methods: Off-resonant-encoded analytical parameter quantification using complex linearized equations (ORACLE) provides analytical solutions for bSSFP profiles.
Machine learning prediction of brain metastasis invasion pattern on brain magnetic resonance imaging scans.
Neurooncol Adv
November 2024
Department of Otolaryngology - Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.
Background: Brain metastasis invasion pattern (BMIP) is an emerging biomarker associated with recurrence-free and overall survival in patients, and differential response to therapy in preclinical models. Currently, BMIP can only be determined from the histopathological examination of surgical specimens, precluding its use as a biomarker prior to therapy initiation. The aim of this study was to investigate the potential of machine learning (ML) approaches to develop a noninvasive magnetic resonance imaging (MRI)-based biomarker for BMIP determination.
View Article and Find Full Text PDFPET/MRI evaluation of hepatobiliary tumors.
Q J Nucl Med Mol Imaging
December 2024
Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA -
Positron-emission tomography magnetic resonance imaging (PET/MRI) has emerged as a powerful hybrid molecular imaging technique in clinical practice, overcoming initial technical challenges to provide comprehensive anatomic and metabolic information. This advanced modality combines the superior soft tissue contrast of MRI with the metabolic insights of PET, offering advantages in hepatobiliary imaging, including improved detection of small liver metastases and reduced radiation exposure. The evolution of PET/MRI technology has been marked by significant advancements, such as the development of MRI-compatible PET detectors and sophisticated motion compensation techniques.
View Article and Find Full Text PDFIdentifying neural circuitry abnormalities in neuropathic pain with transcranial magnetic stimulation and electroencephalogram co-registration.
Neurotherapeutics
November 2024
Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China. Electronic address:
Non-invasive brain stimulation (NIBS) technology such as transcranial magnetic stimulation (TMS) represents a promising treatment for neuropathic pain. However, neural circuitries underlying analgesia remain to be established, which is largely limiting treatment responses. Using TMS and electroencephalogram co-registration (TMS-EEG), this study quantified the circuitry abnormalities in neuropathic pain and their associations with pain symptoms.
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