Two new sterol derivatives isolated from the endophytic fungus YP-2.

Two new sterol derivatives, namely ergosterimide B () and demethylincisterol A (), along with eleven known metabolites (), were isolated from the rice fermentation culture of YP-2. The chemical structures were elucidated by detailed NMR and MS spectroscopic data and by comparison with reported data. Newly isolated compound and known compound were evaluated for their cytotoxicities against the A549 and HepG2 cell lines. Compound showed weak activities with IC values of 11.05 and 19.15 μM, respectively, while exhibited cytotoxicities with IC values of 5.34 and 12.03 μM, respectively, against the tested cell lines.