AI Article Synopsis
- Pyoderma gangrenosum is a chronic skin condition marked by ulcers, linked to an abnormal immune response, with no universally accepted diagnostic or treatment methods.
- In Latin America, diagnosing this condition is complicated by the prevalence of similar bacterial and non-bacterial infections, with Brazil, Mexico, Argentina, and Chile reporting the highest number of cases.
- The ulcerative form is most common and is often associated with conditions like inflammatory bowel disease, with treatments primarily involving systemic corticosteroids and cyclosporine, while biological therapy remains underutilized.
Article Abstract
Pyoderma gangrenosum is a neutrophilic dermatosis characterized by chronic ulcers due to an abnormal immune response. Despite the existence of diagnostic criteria, there is no gold standard for diagnosis or treatment. In Latin America, recognizing and treating pyoderma gangrenosum is even more challenging since skin and soft tissue bacterial and non-bacterial infections are common mimickers. Therefore, this review aims to characterize reported cases of pyoderma gangrenosum in this region in order to assist in the assessment and management of this condition. Brazil, Mexico, Argentina, and Chile are the countries in Latin America that have reported the largest cohort of patients with this disease. The most frequent clinical presentation is the ulcerative form and the most frequently associated conditions are inflammatory bowel diseases, inflammatory arthropaties, and hematologic malignancies. The most common treatment modalities include systemic corticosteroids and cyclosporine. Other reported treatments are methotrexate, dapsone, and cyclophosphamide. Finally, the use of biological therapy is still limited in this region.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939079 | PMC |
| http://dx.doi.org/10.1016/j.abd.2019.06.001 | DOI Listing |
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