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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939178PMC
http://dx.doi.org/10.1016/j.abd.2019.04.003DOI Listing

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Article Synopsis
  • Granuloma annulare is a noninfectious skin condition that appears as red or skin-colored plaques and can be difficult to diagnose due to its varied appearance, requiring correlation between clinical and histological findings.
  • A case involving a 56-year-old woman who developed rashes after a tuberculin skin test is presented, with biopsy confirming granuloma annulare; treatment with topical and oral medications led to resolution of her symptoms.
  • The exact cause of granuloma annulare remains unclear, with various potential triggers like trauma, infections, and immunizations; while it has different forms and mimics other skin diseases, it is generally a benign and self-limited condition.
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Generalized perforating granuloma annulare associated with latent tuberculosis successfully treated with isoniazid: case report and review.

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Clinic of Dermatology and Venereology, University Clinical Center of Serbia, Belgrade, Serbia University of Belgrade, Faculty of Medicine, Department of Dermatology and Venereology, Belgrade, Serbia.

Article Synopsis
  • Generalized perforating granuloma annulare (GPGA) is a rare chronic skin condition with only 31 known cases, characterized by an absence of specific diagnostic criteria and treatment guidelines.
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Article Synopsis
  • Necrobiosis lipoidica is a rare skin disease primarily found in people with diabetes, characterized by granulomatous lesions.
  • The perforating variant of this disease is uncommon, hard to treat, and can be easily identified using dermoscopy.
  • A case study is presented involving a 24-year-old woman with type 1 diabetes suffering from disseminated perforating necrobiosis lipoidica.
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Background: Extensive loss of soft tissue and bone due to neoplasia, trauma, or infection in extremities often leads to amputation.

Case Presentation: We present the case of a 72-year-old female patient presenting with an extended cutaneous squamous cell carcinoma of the lower leg, developed on top of necrobiosis lipoidica. After achieving the R0 resection, a 26 × 20-cm soft tissue and 15-cm tibial bone defect resulted.

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Cutaneous eruptions associated with hemophagocytic lymphohistiocytosis (HLH) have been reported in 6%-63% of patients. Clinical findings of these skin lesions vary widely and include maculopapular rashes, ulcers, and violaceous nodules. Corresponding histologic findings are also variable and are considered nonspecific.

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