AI Article Synopsis
- New antibiotics are critically needed to combat drug-resistant bacteria.
- A new light-activated rhenium complex has been created, showing effectiveness against resistant strains like S. aureus and E. coli.
- Research indicates that this complex works through two different mechanisms, based on its effectiveness against mutant strains and how well it is taken up by cells.
Article Abstract
New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687258 | PMC |
| http://dx.doi.org/10.1002/chem.201904689 | DOI Listing |
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Article Synopsis
- New antibiotics are critically needed to combat drug-resistant bacteria.
- A new light-activated rhenium complex has been created, showing effectiveness against resistant strains like S. aureus and E. coli.
- Research indicates that this complex works through two different mechanisms, based on its effectiveness against mutant strains and how well it is taken up by cells.
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