AI Article Synopsis
- The study assessed the impact of a short-term oral elemental diet (ED) on long-term body weight loss after gastrectomy, focusing on its efficacy during the early recovery period post-surgery.
- Patients were randomly assigned to receive either a regular diet or the elemental diet in addition to their regular meals, with changes in body weight measured after one year.
- Results showed that the ED significantly reduced body weight loss one year post-surgery specifically for those who had total gastrectomy, suggesting that this nutritional intervention can be beneficial in managing long-term body weight outcomes.
Article Abstract
Aim: The present study aimed to evaluate the efficacy of short-term nutritional intervention with an oral elemental diet (ED; Elental; EA Pharma Co., Ltd, Tokyo, Japan) at 300 kcal/day for 6-8 weeks in the early post-gastrectomy period on postoperative long-term body weight loss (BWL).
Methods: We analyzed consecutive patients who were randomly divided to receive the regular diet with or without ED. The control group received regular diet alone post-gastrectomy, whereas the ED group received 300 kcal ED plus regular diet for 6-8 weeks. Primary endpoint was percentage (%) BWL (body weight loss; body weight before surgery minus that at postoperative 1 year) by surgical type. Secondary endpoints included changes in nutrition-related blood parameters.
Results: Of the patients in the original trial, 106 were eligible for efficacy analyses. %BWL at postoperative 1 year was significantly lower in the ED group than in the control group among patients who underwent total gastrectomy (TG) (n = 19 and n = 17, respectively; 9.66 ± 5.98% [95% confidence interval, CI: 6.77-12.54] vs 15.11 ± 6.78% [95% CI: 11.63-18.60], = .015), but not in patients who underwent distal gastrectomy (n = 38 and n = 32, respectively; 5.81 ± 7.91% [95% CI: 3.21-8.41] vs 5.96 ± 6.20% [95% CI: 3.72-8.19], = .933). In multivariate analysis, ED was the only factor affecting %BWL at postoperative 1 year among patients who underwent TG.
Conclusions: Daily nutritional intervention (300 kcal/day ED) for 6-8 weeks reduced %BWL not only at postoperative 6-8 weeks but also at 1 year in patients who underwent TG.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875942 | PMC |
| http://dx.doi.org/10.1002/ags3.12290 | DOI Listing |
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