AI Article Synopsis
- DNA usually looks like a spiral staircase called a B-form helix, but it can also twist into different shapes like G-quadruplex (G4), which is one of those shapes.
- Recently, scientists found out where these G4 shapes can be found in DNA and figured out they might help with important jobs in cells, like copying DNA and making RNA.
- In this review, researchers are particularly looking at how G4 structures might be related to brain functions and could help us understand and treat brain-related diseases.
Article Abstract
The most common form of DNA is a right-handed helix, the B-form DNA. DNA can also adopt a variety of alternative conformations, termed non-B-form DNA secondary structures, including the G-quadruplex (G4). Furthermore, non-canonical RNA G4 secondary structures are also observed. Recent bioinformatics analysis revealed genomic positions of G4. In addition, G4 formation may be associated with various biological functions, including DNA replication, transcription, epigenetic modification, and RNA metabolism. In this review, we focus on G4 structures in neuronal functions, which may have important roles reveal mechanisms underlying neurological disorders. In addition, we discuss the potential of G4s as a therapeutic target for neurological diseases.
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| http://dx.doi.org/10.1254/fpj.154.294 | DOI Listing |
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