AI Article Synopsis
- A study isolated new compounds from the methanol extract of Diospyros maritima, specifically three new oleanane-type and one new ursane-type triterpene glucosides, named ebenamariosides A-D, along with two megastigmanes.
- The structures of these compounds were determined using advanced NMR spectroscopy and confirmed through enzymatic hydrolysis, while the megastigmanes' structures were established using spectroscopic methods and Mosher's technique.
- Tests for cytotoxicity showed that neither the triterpene glucosides nor their degradation products exhibited significant activity.
Article Abstract
The 1-BuOH-soluble fraction of the methanol (MeOH) extract of Diospyros maritima was separated by chromatographic techniques to give three new oleanane-type and one new ursane-type triterpene glucoside, named ebenamariosides A-D (1-4); two megastigmanes were also isolated. The structures of triterpene glucosides was elucidated with extensive investigation by one and two dimensional NMR spectroscopy and the structures were confirmed by partial enzymatic hydrolyses to give the corresponding mono-glucosides and aglycones. The structures of the megastigmanes, including their absolute stereochemistries, were elucidated by spectroscopic evidence and by the modified Mosher's method. Two megastigmanes were chemically correlated and their absolute structures were unambiguously determined. The cytotoxicity of the triterpene glucosides and their degradation products were assayed. They did not show any significant activity.
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| http://dx.doi.org/10.1248/cpb.c19-00803 | DOI Listing |
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