Purpose: To provide a global scale report on a representative sample of the clinical embryology community depicting the practice of discarding supernumerary IVF embryos.
Methods: A web-based questionnaire titled "Anonymous questionnaire on embryo disposal practices" was designed in order to ensure anonymous participation of practicing clinical embryologists around the world.
Results: During a data collection period of 8 months, 703 filled-in questionnaires from 65 countries were acquired. According to the data acquired, the majority of practitioners, dispose of embryos by placing them directly in a trash can strictly dedicated for embryo disposal for both fresh and frozen cycles (39% and 36.7% respectively). Moreover, 66.4% of practitioners discard the embryos separately-case by case-at different time points during the day. Over half of embryologists (54%) wait until day 6 to discard the surplus embryos, while 65.5% do not implement a specially allocated incubator space as a designated waiting area prior to disposal. The majority of 63.1% reported that this is a witnessed procedure. The vast majority of embryologists (93%) do not employ different protocols for different groups of patients. Nonetheless, 17.8% reported the request to perform a ceremony for these embryos. Assessing the embryologists' perspective, 59.5% of participants stated that the embryology practice would benefit from a universally accepted and practiced protocol.
Conclusion(s): This study uniquely provides insight into global embryo disposal practices and trends. Results highlight the divergence between reported practices, while indicating the significance on standardization of practice, with embryologists acknowledging the need for a universally accepted protocol implementation.
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http://dx.doi.org/10.1007/s10815-019-01592-w | DOI Listing |
Biochem Pharmacol
December 2024
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, PR China. Electronic address:
Sleep deprivation (SD) causes circadian misalignment, and circadian clock disruption is associated with metabolic diseases such as obesity, insulin resistance, and diabetes. However, the underlying mechanism for SD-induced circadian clock disruption as well as metabolic enzyme changes is still lacking. Here, we developed SD sensitizes mice with disrupted circadian rhythms to demonstrate the regulation role and mechanism of SD in UDP-glucuronosyltransferases (UGTs) expression and the metabolism of corresponding substrates.
View Article and Find Full Text PDFBr Poult Sci
November 2024
School of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
1. Building on established understandings regarding hormonal and metabolic-driven processes of avian embryo's growth and development, this paper proposes a novel method, focusing on sex-related dimorphism. Such processes involve crucial activities, .
View Article and Find Full Text PDFWater Res
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, NO. 163 Xianlin Avenue, Nanjing 210023, China. Electronic address:
With the growing consensus of emerging pollutants and biological toxicity risks in wastewater treatment plant (WWTP) effluents, traditional water quality management based on general chemical parameters no longer meets the new challenges. Here, a first-hand dataset containing 9 conventional parameters, 22 mental and inorganic ions, 25 biotoxicity parameters, and 54 emerging pollutants from effluents of 176 municipal WWTPs across China were measured. Four clustering algorithms and five classification algorithms were applied to 65 well-performing models to determine a novel evaluation parameter system.
View Article and Find Full Text PDFHum Reprod
December 2024
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Study Question: Are there significant differences in fertility outcomes between transferring two cleavage-stage embryos in a single fresh cycle and transferring one cleavage-stage embryo in a fresh cycle and one blastocyst-stage embryo in the subsequent frozen-thawed cycle?
Summary Answer: In women aged <38 years with two embryos available, transferring one cleavage-stage embryo in a fresh cycle and one blastocyst-stage embryo in the subsequent frozen-thawed cycle increased live birth rates and decreased multiple live birth rates compared to transferring two cleavage-stage embryos in a single fresh cycle.
What Is Known Already: The strategy of repeated single embryo transfer (SET) has emerged as a solution to address the reduced live birth rates associated with SET per cycle. There is substantial evidence indicating that the cumulative live birth rate after repeated SET is comparable to that of double embryo transfer (DET), while significantly reducing the incidence of multiple pregnancies.
Fertil Steril
December 2024
Department of Obstetrics and Gynecology, Louisiana State University Health- Shreveport, Shreveport, Louisiana; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi; Positive Steps Fertility, Madison, Mississippi.
We share experiences in advocating to defend in vitro fertilization (IVF) in Virginia, Missouri, and Mississippi; provide historical context on the "Personhood" anti-IVF movement; and discuss why "embryo donation" is a more accurate term than "embryo adoption." Some individuals and communities have a deeply held belief that a fertilized oocyte is a very early human life, and we will likely never change their minds. In the fertility community, most providers consider embryos to be an important part of the continuum between gametes (sperm and eggs) to live birth.
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