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In-silico identification of novel DDI2 inhibitor in glioblastoma repurposing FDA approved drugs using molecular docking and MD simulation study.
J Biomol Struct Dyn
March 2024
School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India.
Glioblastoma, the most severe form of brain tumor and a leading cause of death within a year of diagnosis, is characterized by excessive protein synthesis and folding in the lumen of the endoplasmic reticulum (ER), leading to increased ER stress in the cells of GBM tissues. To mitigate this stress the cancer cells have intelligently adopted a plethora of response mechanisms and Unfolded Protein Response (UPR) is one of those. To bear with this exhaustive situation cells upregulate a strong protein degradation system in form of 26S proteasome and blocking of proteasomal gene synthesis may be a potential therapeutic action against GBM.
View Article and Find Full Text PDFEfficacy and Safety of Peripherally Acting Mu-Opioid Receptor Antagonists for the Treatment of Opioid-Induced Constipation: A Bayesian Network Meta-analysis.
Pain Med
November 2020
Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Objective: To assess the efficacy and safety of peripherally acting mu-opioid receptor antagonists (PAMORAs) for the treatment of opioid-induced constipation (OIC).
Methods: Randomized controlled trials (RCTs) were searched for OIC therapy comparing PAMORAs with placebo. Both a pairwise and network meta-analysis were performed.
Response to: "Alvimopan and outcome after colectomy?".
Surgery
March 2020
Department of Surgery, Medical College of Wisconsin, Milwaukee, WI. Electronic address:
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.
Cochrane Database Syst Rev
June 2018
Marie Curie Palliative Care Research Department, UCL Division of Psychiatry, 6th Floor, Maple House, 149 Tottenham Court Road, London, UK, W1T 7NF.
Background: Opioid-induced bowel dysfunction (OIBD) is characterised by constipation, incomplete evacuation, bloating, and gastric reflux. It is one of the major adverse events of treatment for pain in cancer and in palliative care, resulting in increased morbidity and reduced quality of life.This is an update of two Cochrane reviews.
View Article and Find Full Text PDFStereoselective HPLC separation of alvimopan on cellulose-based immobilized polysaccharide as a chiral stationary phase.
Chirality
May 2018
Fluorescence Spectroscopy Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur, 416 004, Maharashtra, India.
Chiral separation by normal phase high performance liquid chromatography is one of the most powerful technique to quantify the chiral purity of the compounds. In this study, a novel, simple, and specific analytical method was proposed to ascertain the chiral purity of alvimopan (ALV). The normal phase HPLC method was developed based on cellulose tris (3,5-dichlorophenylcarbamate) stationary phase.
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