AI Article Synopsis
- - Granulomatosis with polyangiitis (GPA) is an inflammatory disease linked to small and medium-sized vessel damage, which presents complexities in diagnosis due to its various symptoms affecting multiple organs.
- - A critical component of diagnosing GPA involves the detection of anti-neutrophil cytoplasmic antibodies (ANCAs) and collaboration with pathologists to avoid misdiagnosis, such as mistaking it for metastatic cancer.
- - In a reported case, a woman initially suspected of having metastatic cancer was correctly diagnosed with GPA through a breast biopsy, leading to successful treatment and full recovery.
Article Abstract
Granulomatosis with polyangiitis (GPA) is a systemic inflammatory disease, characterized by the presence of necrotizing vasculitis of small and medium-sized vessels, granulomatous inflammation and anti-neutrophil cytoplasmic antibodies (ANCAs). The diagnosis can be challenging due to the variable clinical presentation and possible involvement of virtually all organ systems. A correct diagnosis is indispensable for a timely start of medical treatment and to avoid unnecessary surgery. Therefore, cooperation with and the input of the pathologist is crucial. We report a case of a woman presenting with suspected metastatic cancer. The diagnosis of GPA was made mainly based on breast biopsy, and the patient was treated accordingly, with full recovery. This report provides a case description and a brief review of the literature.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002001 | PMC |
| http://dx.doi.org/10.5152/eurjrheum.2019.19065 | DOI Listing |
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