With single-level data, Yuan, Cheng and Maxwell developed a two-level regression model for more accurate moderation analysis. This article extends the two-level regression model to a two-level moderated latent variable (2MLV) model, and uses a Bayesian approach to estimate and test the moderation effects. Monte Carlo results indicate that: 1) the new method yields more accurate estimate of the interaction effect than those via the product-indicator (PI) approach and latent variable interaction (LVI) with single-level model, both are also estimated via Bayesian method; 2) the coverage rates of the credibility interval following the 2MLV model are closer to the nominal 95% than those following the other methods; 3) the test for the existence of the moderation effect is more reliable in controlling Type I errors than both PI and LVI, especially under heteroscedasticity conditions. Moreover, a more interpretable measure of effect size is developed based on the 2MLV model, which directly answers the question as to what extent a moderator can account for the change of the coefficient between the predictor and the outcome variable. A real data example illustrates the application of the new method.
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http://dx.doi.org/10.1080/00273171.2019.1689350 | DOI Listing |
J Sci Med Sport
December 2024
Faculty of Education, University of the Ryukyus, Japan.
Objectives: To examine the validity and reliability of the Simple Motor Competence-check for Kids (SMC-Kids), which was developed to assess motor development in preschool children.
Design: A cross-sectional and repeated-measures design.
Methods: To assess validity, 71 children aged 4-6 years completed the Test of Gross Motor Development-3 (TGMD-3) and SMC-Kids (10 m shuttle run and paper ball throw).
J Psychiatr Res
December 2024
Research Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom; Anna Freud National Centre for Children and Families, London, United Kingdom.
Background: The present study examines the interplay between epistemic stance, attachment dimensions, and childhood trauma in relation to specific demographic factors and mental health outcomes. This study aims to understand how these factors form distinct profiles among individuals, to identify those at risk of mental health concerns.
Method: Latent Profile Analysis (LPA) was employed on a dataset from the general population (n = 500) to identify subgroups of individuals based on their epistemic stance (mistrust and credulity), attachment dimensions, and childhood trauma.
Alzheimers Dement
December 2024
Allen Institute for Brain Science, Seattle, WA, USA.
Background: Alzheimer's Disease is marked by the gradual aggregation of pathological proteins, Tau and beta-amyloid, throughout various areas of the brain. The progression of these pathologies follows a consistent pattern, impacting various cellular populations as it advances through each brain region. Previously, we used Bayesian algorithms to create a continuous progression score to mathematically capture the collective aggregation of multiple pathological variables within a specific brain region.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Massachusetts Chan Medical School, Worcester, MA, USA.
Background: Several studies have found that oral and gut microbiome and their byproducts can impact Alzheimer's Disease (AD). The objective of our study is to analyze metagenomic sequencing data from paired oral and fecal microbiomes, along with clinical variables, to identify communities of bacteria associated with AD. This research aims to improve our understanding of the microbiome community matrix, and how these communities interact and correlate with AD status compared to healthy controls (HC) through an oral-gut microbial axis.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
College of Public Health, University of Kentucky, Lexington, KY, USA.
Background: We recently reported genetic associations with dementia-related proteinopathies. Using multidimensional generalized partial credit modeling, we constructed three continuous latent variables, corresponding to TDP-43, Aβ/Tau, and a-synuclein related neuropathology endophenotype scores.
Method: Participant data were drawn from the National Alzheimer's Coordinating Center (NACC) neuropathology (NP) data (from the September 2023 data freeze) linked to Alzheimer's Disease Genetics Consortium (ADGC) genotype data.
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