Antimicrobial bisabolane-type sesquiterpenoids from the deep-sea sediment-derived fungus SD-330.

One new aromatic bisabolene-type sesquiterpenoid (), along with four known analogues () were isolated and identified from the deep-sea sediment-derived fungus SD-330. Their structures were elucidated by NMR, HRESIMS, X-ray crystallographic analysis, and quantum chemical ECD calculations as well as comparison of those data with literature data. Compounds were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds , and exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as , , and , with the MIC values ranging from 1.0 to 8.0 μg/mL.