Introduction: Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are classified as spondyloarthritis (SpA), a group of inflammatory rheumatic diseases with complex genetic etiology. Toll-like receptors (TLRs) have an important role in the mechanism of innate immunity and may influence inflammatory responses. Polymorphisms in genes that lead to changes in these receptors or that interfere with the transcription rates of mRNA TLR may be involved in the chronic inflammatory immune response observed in SpA. Currently, there is a lack of studies associating genetic polymorphisms in and SpA.
Objective: Therefore, this case-control study is aimed at analyzing the influence of the respective SNPs on , , and and in the immunopathogenesis of SpA.
Methods: The polymorphisms genotyped by PCR-RFLP were , , and and . The was performed by PCR-SSP.
Results: Logistic regression analysis showed a strong association between SNPs in and and susceptibility to SpA (OR = 12.56; CI = 6.5-25.9 and OR = 1.62; CI = 1.20-2.21, respectively). No association was observed among and polymorphisms ( = 0.72), nor among BASDAI and polymorphisms ( = 0.85).
Discussion: Our findings suggest that polymorphisms in and genes may contribute to the immunopathogenesis of the SpA. The , , and polymorphisms were associated with the risk of SpA development, in this study, and lead to significant changes in the innate and adaptive immune response profile, as well as the maintenance of the regulation of immunological mechanisms.
Conclusion: The polymorphism for the and the haplotypes appear to be involved in the development of clinical forms of SpA and can be a possible therapeutic target for the spondyloarthritis.
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| http://dx.doi.org/10.1155/2019/1492092 | DOI Listing |
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