Is Associated with Vaginal Dysbiosis in Healthy Pregnant Women: A Preliminary Study.

Biomed Res Int

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.

Published: April 2020

Vaginal dysbiosis has been identified to be associated with adverse pregnancy outcomes, such as preterm delivery and premature rupture of membranes. However, the overall structure and composition of vaginal microbiota in different trimesters of the pregnant women has not been fully elucidated. In this study, the physiological changes of the vaginal microbiota in healthy pregnant women were investigated. A total of 83 healthy pregnant participants were enrolled, who are in the first, second, or third pregnancy trimester. Quantitative real-time PCR was used to explore the abundant bacteria in the vaginal microbiota. No significant difference in the abundance of , , , , /, or was found among different trimesters, except . Compared with the first pregnancy trimester, the abundance of decreased in the second and third trimester while the abundance of was increased in the second trimester. Moreover, we also found that vaginal cleanliness is correlated with the present of , , and and leukocyte esterase is associated with , , , , /, and . For those whose vaginal cleanliness raised or leukocyte esterase became positive, the richness of increased, while that of decreased significantly. Our present data indicated that the altered vaginal microbiota, mainly , could be observed among different trimesters of pregnancy and could be considered as a potential bacterial marker for evaluating vaginal cleanliness and leukocyte esterase.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855029PMC
http://dx.doi.org/10.1155/2019/6079734DOI Listing

Publication Analysis

Top Keywords

vaginal microbiota
16
healthy pregnant
12
pregnant women
12
vaginal cleanliness
12
leukocyte esterase
12
associated vaginal
8
vaginal dysbiosis
8
vaginal
8
second third
8
pregnancy trimester
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!