AI Article Synopsis
- The text discusses a new synthesis method for 4-tosyl-1-arylimidazoles using aryl azides in a Van Leusen reaction mediated by TosMIC.
- It highlights that two TosMIC molecules play different roles in the reaction process.
- A unique fragmentation mechanism occurs with the second TosMIC molecule, leading to the incorporation of a C-H bond in the final product.
Article Abstract
Considering aryl azides as electrophilic partners for the TosMIC mediated Van Leusen reaction, a novel multicomponent synthesis of 4-tosyl-1-arylimidazoles is reported. In this transformation, two molecules of TosMIC participate in the reaction mechanism in two different ways, with the second molecule undergoing a novel type of fragmentation resulting in the incorporation of a C-H into the final product.
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| http://dx.doi.org/10.1021/acs.joc.9b02546 | DOI Listing |
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