AI Article Synopsis
- - Mozambique has a high prevalence of tuberculosis (TB), particularly with multidrug-resistant strains and co-infection with HIV, making it a significant public health concern.
- - A study analyzed 79 suspected drug-resistant TB strains from Beira using spoligotyping and compared them to existing data, revealing four main clades of M. tuberculosis—Latin-American-Mediterranean, East-African-Indian, Beijing, and T.
- - The findings indicate that the population genetic structure of M. tuberculosis in Beira is consistent with that found throughout Mozambique, highlighting a shared genetic background of the bacteria in the region.
Article Abstract
Introduction: Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambique comparing them with genotypes in the country.
Methods: We performed spoligotyping of 79 M. tuberculosis suspected of DR-TB compared all spoligotype patterns published on the international database and PubMed.
Results: Both in Beira and Mozambique (n=578), the main clades were Latin-American-Mediterranean, East-African-Indian, Beijing and T, with no extensively DR TB cases.
Conclusions: Beira and Mozambique share the same population genetic structure of M. tuberculosis.
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| http://dx.doi.org/10.1590/0037-8682-0257-2019 | DOI Listing |
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