Controlled synthesis of , -dimethylarylsulfonamide derivatives as nematicidal agents.

Gramine can be intelligently and efficiently supplied with , -dimethylamino group and then reacted with the corresponding sulfonyl chlorides to synthesize , -dimethylarylsulfonamides. We herein designed and controlled synthesis of , -dimethylarylsulfonamide derivatives, and first reported the results of the nematicidal activity of 15 title compounds against , respectively. Among all of the title derivatives, compounds , , , and exhibited potent nematicidal activity with median lethal concentration (LC) values ranging from 0.22 to 0.26 mg/L. Most noteworthy, -dimethyl-4-methoxyphenylsulfonamide () and -dimethyl-8-quinolinesulfonamide () showed the best promising and pronounced nematicidal activity, with LC values of 0.2381 and 0.2259 mg/L, respectively.