AI Article Synopsis
- - Two-photon fluorescence microscopy is essential for cellular imaging, typically using established fluorescent probes.
- - The study introduces a new fluorophore, azulene, that acts as a two-photon fluorescent probe for bioimaging.
- - This azulene-based chemodosimeter is effective in detecting reactive oxygen species, specifically peroxynitrite, with great cell penetration, selectivity, no cytotoxicity, and strong photostability.
Article Abstract
Two-photon fluorescence microscopy has become an indispensable technique for cellular imaging. Whereas most two-photon fluorescent probes rely on well-known fluorophores, here we report a new fluorophore for bioimaging, namely azulene. A chemodosimeter, comprising a boronate ester receptor motif conjugated to an appropriately substituted azulene, is shown to be an effective two-photon fluorescent probe for reactive oxygen species, showing good cell penetration, high selectivity for peroxynitrite, no cytotoxicity, and excellent photostability.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909233 | PMC |
| http://dx.doi.org/10.1021/jacs.9b09813 | DOI Listing |
Publication Analysis
Top Keywords
fluorescent probe
8
reactive oxygen
8
two-photon fluorescent
8
azulene-derived fluorescent
4
probe bioimaging
4
bioimaging detection
4
detection reactive
4
oxygen nitrogen
4
nitrogen species
4
two-photon
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!