Background: Oropharyngeal squamous cell carcinomas (OPSCC) can occur in either tonsillar related areas (TRA) or nontonsillar areas (nTRA). The prognostic differences between these sites are unclear. This study investigated this question using the National Cancer Database (NCDB), controlling for other confounders including human papillomavirus (HPV) status.
Methods: This NCDB study was conducted by stratifying the HPV-positive oropharyngeal cancer cohort into two primary groups, TRA and nTRA. Kaplan Meier survival analysis was stratified according to HPV status, and further analysis was conducted using multivariable Cox regression.
Results: A total of 23 297 patients were included in this study. In the multivariable cox regression analysis, OPSCC subsite was found to be an independent prognostic factor for survival (TRA vs nTRA HR: 0.76, 95% CI: 0.67-0.86, P < .0001).
Conclusion: In this large cohort, OPSCC subsite was found to be an independent prognostic factor for survival.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.26019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reflection on Transoral Robotic Surgery vs Transoral Laser Microsurgery in HPV-Positive Oropharyngeal Squamous Cell Carcinoma-Reply.
JAMA Otolaryngol Head Neck Surg
January 2025
Liverpool Head and Neck Centre, University of Liverpool, Liverpool, England.
Reflection on Transoral Robotic Surgery vs Transoral Laser Microsurgery in HPV-Positive Oropharyngeal Squamous Cell Carcinoma.
JAMA Otolaryngol Head Neck Surg
January 2025
Department of Microbiology, Centre for infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
[Epidemiology and prevention of oropharyngeal cancer : Summary of the new German S3 guideline].
HNO
January 2025
Klinik und Poliklinik für Hals‑, Nasen‑, Ohrenheilkunde, Universitätsklinikum Leipzig, Universität Leipzig, Liebigstraße 10, 04103, Leipzig, Deutschland.
Due to the association with the causal human papillomavirus 16 (HPV16) infection, oropharyngeal squamous cell carcinoma is now separated into two distinct entities depending on HPV16 positivity. More recent data show a diversified picture of the importance and prevalence of the surrogate parameter p16 (discordance) for a definitive HPV16 association, which varies worldwide. In the context of preventive options, vaccination is of major importance and HPV screening of healthy people of less importance.
View Article and Find Full Text PDFArtificial intelligence for image recognition in diagnosing oral and oropharyngeal cancer and leukoplakia.
Sci Rep
January 2025
Department of Otolaryngology Head and Neck Surgery, Technical University Munich, Munich, Germany.
Visual diagnosis is one of the key features of squamous cell carcinoma of the oral cavity (OSCC) and oropharynx (OPSCC), both subsets of head and neck squamous cell carcinoma (HNSCC) with a heterogeneous clinical appearance. Advancements in artificial intelligence led to Image recognition being introduced recently into large language models (LLMs) such as ChatGPT 4.0.
View Article and Find Full Text PDFDisparities in stage at diagnosis of head and neck tumours in Brazil: a comprehensive analysis of hospital-based cancer registries.
Lancet Reg Health Am
February 2025
Molecular Carcinogenesis Program, Coordination of Research and Innovation, Brazilian Nacional Cancer Institute (INCA), Rio de Janeiro, Brazil.
Background: The advanced stage of cancer is a determining factor in poor prognosis. Head and neck squamous cell carcinomas (HNSCC) are highly incident in Brazil, but similarly to many Low and Middle-Income Countries, data is limited regarding the proportion of tumours diagnosed at advanced clinical stages and the main factors associated with it. Therefore, this study aimed to identify the factors associated with advanced stage of HNSCC in Brazil.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!