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Filename: controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Filename: controllers/Detail.php
Line Number: 249
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Function: _error_handler
File: /var/www/html/index.php
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Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Message: Trying to access array offset on value of type null
Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
Line: 249
Function: _error_handler
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Filename: models/Detail_model.php
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Function: strpos
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Function: insertAPISummary
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Function: str_replace
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Function: formatAIDetailSummary
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Filename: controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Function: _error_handler
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Function: require_once
Since the emergence of cancer nanomedicine, researchers have had intense interest in developing nanoparticles (NPs) that can specifically target diseased sites while avoiding healthy tissue to mitigate the off-target effects seen with conventional treatments like chemotherapy. Initial endeavors focused on the bioconjugation of targeting agents to NPs, and more recently, researchers have begun to develop biomimetic NP platforms that can avoid immune recognition to maximally accumulate in tumors. In this review, we describe the advantages and limitations of each of these targeting strategies. First, we review developments in bioconjugation strategies, where NPs are coated with biomolecules such as antibodies, aptamers, peptides, and small molecules to enable cell-specific binding. While bioconjugated NPs offer many exciting features and have improved pharmacokinetics and biodistribution relative to unmodified NPs, they are still recognized by the body as "foreign", resulting in their clearance by the mononuclear phagocytic system (MPS). To overcome this limitation, researchers have recently begun to investigate biomimetic approaches that can hide NPs from immune recognition and reduce clearance by the MPS. These biomimetic NPs fall into two distinct categories: synthetic NPs that present naturally occurring structures, and NPs that are completely disguised by natural structures. Overall, bioconjugated and biomimetic NPs have substantial potential to improve upon conventional treatments by reducing off-target effects through site-specific delivery, and they show great promise for future standards of care. Here, we provide a summary of each strategy, discuss considerations for their design moving forward, and highlight their potential clinical impact on cancer therapy.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879063 | PMC |
http://dx.doi.org/10.1007/s12274-018-2083-z | DOI Listing |
Front Chem
December 2024
Chemistry Department, NanoStruc Research Group, Faculty of Science, Helwan University, Cairo, Egypt.
Introduction: This study investigates the synthesis of silver nanoparticles (Ag NPs) using Helianthemum lippii extract and evaluates their photoprotective, anti-hemolytic, antibacterial, and anti-inflammatory properties compared to various extract fractions, including total aqueous extract (AE), flavonoid monoglycosides (FMG), flavonoid diglycosides/triglycosides (FDG/FTG), tannins (TN), and anthocyanins (AC). Helianthemum lippii is rich in bioactive compounds such as caffeic acid, p-coumaric acid, and gallic acid, known for their therapeutic potential. This study aims to determine whether embedding these phytochemicals into Ag NPs enhances their biomedical applications compared to the natural extract fractions.
View Article and Find Full Text PDFWater Res X
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, Shanghai Institute of Pollution Control and Ecological Security, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.
Solar evaporation exhibits significant potential for the treatment of high-salt organic wastewater. However, it's also confronted with challenges due to the accumulation of organic pollutants and salts in the concentrated wastewater following evaporation, which compromises the long-term stability of evaporation unit and complicates subsequent treatment processes. To address these challenges, a volumetric solar interfacial evaporation (V-SIE) system by integrating FeO HO nanofluids and peroxydisulfate (PDS) were proposed in this study.
View Article and Find Full Text PDFJ Environ Health Sci Eng
June 2025
Department of Chemistry, Ondokuz Mayis University, Samsun, Turkey.
Unlabelled: Today, nanoplastics (NPs) are a growing environmental concern due to their persistence and widespread distribution, posing risks to ecosystems and human health. Their ability to transport pollutants makes them particularly dangerous, underscoring the urgent need for effective removal methods. Herein, we report the synthesis of an environmentally friendly material that enables the magnetic removal of polystyrene nanoparticles (PSNPs) from aqueous solutions by green chemistry approach.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Applied and Environmental Chemistry, University of Szeged, Szeged, Hungary.
Currently, the increasing use of nickel metal-organic frameworks (Ni-MOF) and nickel oxide nanoparticles (NiO NPs) has raised concerns regarding their potential environmental impact on wastewater treatment systems. Herein, the responses of aerobic granular sludge (AGS) and algal-bacterial aerobic granular sludge (AB-AGS) to Ni-MOF and NiO NPs were investigated. The results showed that Ni-MOF concentrations of 50, 100, and 200 mg/L significantly reduced nutrient removal in both systems, particularly affecting ammonia, nitrite, and phosphorus removal, while denitrification processes remained stable.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Condensed Matter Physics, Faculty of Physics, University of Tabriz, 29 Bahman Blvd., Tabriz, Iran.
Research on hydroxyapatite (HAP) coatings for bone tissue applications has been investigated for decades due to their significant osteoconductive and bioactivity properties. HAP closely resembles the mineral component of human bone, making it ideal for biomedical applications such as implants. This study investigates the synthesis of hydroxyapatite nanoparticles (HAP-NPs) via the microemulsion method, which is essential for creating HAP coatings on the Ti-6Al-4V substrate.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!