AI Article Synopsis
- This study explores the absorption and metabolism of a specific flavonoid glycoside, quercetin-3-O-sophoroside, found in foods like brassica vegetables and red raspberries.
- Researchers discovered that this compound can be absorbed intact in rats, without breaking down into its basic components, suggesting that the sugar structure may influence how flavonoid glycosides are absorbed.
- The findings include the presence of various metabolized forms of quercetin sophoroside in blood and cecal contents, indicating complex interactions in the digestive system.
Article Abstract
Although flavonoid sophorosides are common glycosides in brassica vegetables, red raspberries and other food plants, there is a lack of studies of absorption and metabolism of any sophoroside. The aim of this study was to characterize the absorption, phase II metabolism and microbial catabolism of quercetin-3-O-sophoroside, compared to that of quercetin aglycone. Quercetin-3-O-sophoroside was purified from Apocynum venetum and characterized by MS, H and C NMR. Using an in situ rat gut model, we found intact, methylated, sulfated and both methylated and sulfated quercetin sophoroside in the plasma following jejunal introduction of the sophoroside; we found derivatives of benzoic acid, phenylacetic acid, and phenyl propionic acid in the cecal contents following cecal introduction. This novel finding, that quercetin sophoroside was absorbed intact, without deglycosylation, points to a possible role for the terminal sugar and/or the type of linkage among glycosidic moieties in the mechanism of absorption of flavonoid glycosides.
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| http://dx.doi.org/10.1016/j.foodchem.2019.125880 | DOI Listing |
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