We analyze the packing properties of simulated three-dimensional polydisperse samples of spherical particles assembled by mechanical compaction with zero interparticle friction, leading to random close-packed configurations of the highest packing fraction. The particle size distributions are generated from the incomplete beta distribution with three parameters: A size span and two shape parameters that control the curvature of the distribution function. For each size distribution, the number of particles is determined by accounting for the statistical representativity of all particle size classes in terms of both the numbers and volumes of particles. Remarkably, the packing fraction increases, up to a small variability, with an effective size span, known as the coefficient of uniformity, that combines the three control parameters of the distribution. The local particle environments are characterized by the particle connectivities and anisotropies, which unveil the class of particles with four contact neighbors as the largest class with an increasing population as a function of size span, indicating the higher stability of particles trapped by four larger particles. As a result of increasing topological inhomogeneity of the packings, the force distributions get increasingly broader with increasing effective size span. Finally, we find that larger particles do not always carry stronger average stresses, in particular when the particle size distribution allows for a sufficiently large number of small particles.
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http://dx.doi.org/10.1103/PhysRevE.100.042906 | DOI Listing |
Arch Dermatol Res
January 2025
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia.
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by dry skin, severe itching, redness, and inflammation. Its complex etiology, involving genetic, immunological, and environmental factors, necessitates innovative therapeutic approaches. This study investigates nanostructured lipid carriers (NLCs) formulated with traditional fermented coconut (Cocos nucifera L.
View Article and Find Full Text PDFPrev Med
January 2025
School of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada; ParticipACTION, Toronto, ON, Canada.
Objective: To update the evidence on the effects of financial incentives (FI) on physical activity (PA) in adults.
Methods: A systematic search of nine databases (Medline, EMBASE, PsychINFO, Scopus, Web of Science, CINAHL, EconLit, SPORTDiscus, and Cochrane) was conducted to identify randomised controlled trials (RCTs) and pilot RCTs published between June 1, 2018 and March 31, 2024 examining FI-for-PA interventions. 'Vote counting' and random-effects meta-analyses assessed short- (<6 months) and long-term (≥6 months) FI effects, as well as impact during follow-up (incentive withdrawal).
Proc Natl Acad Sci U S A
January 2025
Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
The crowded bacterial cytoplasm is composed of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich spatial organization and apparent anomalous diffusion of intracellular components, although this has not been tested directly. Here, we use biplane microscopy to track the 3D motion of self-assembled bacterial genetically encoded multimeric nanoparticles (bGEMs) with tunable size (20 to 50 nm) and charge (-3,240 to +2,700 e) in live cells.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Pharmaceutics and Industrial Pharmacy, Pharm D Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt.
Wound management remains a significant challenge due to complications such as delayed healing and microbial infections, particularly in the conditions like diabetes mellitus, vascular disorders, and immunosuppression. This study aimed to develop a chitosan-coated virgin coconut oil-asiatic acid-loaded nanoemulsion gel (CS-ASA-NEG) to enhance wound healing outcomes. A central composite design (CCD) was employed using Design Expert 11 software to optimize the nanoemulsion formulation, with ternary phase diagrams (TPD) evaluating stable regions for Tween 20: Span 80 (T20:S80) ratios.
View Article and Find Full Text PDFRev Argent Microbiol
January 2025
Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
Methicillin-resistant Staphylococcus aureus (MRSA) causes a wide range of infections and contributes to elevated morbidity, mortality, and healthcare costs. Herbal compounds combined with drug delivery systems could be an effective alternative option for treating resistant bacteria. This study evaluates the antimicrobial prowess of carvacrol-loaded niosomes against MRSA strains.
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