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Neferine Attenuates Aging-Related Liver Dysfunction by Suppressing Cellular Aging via Mitochondrial Reactivation.
Biol Pharm Bull
November 2024
Department of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University.
Cellular aging causes declining cell functionality, gradually disrupting cellular homeostasis. Mitochondria are crucial in numerous metabolic processes, including the electron transport chain and fatty acid β-oxidation. Mitochondrial dysfunction is closely linked to aging-related liver dysfunction because it impairs fatty acid metabolism, potentially leading to nonalcoholic fatty liver disease.
View Article and Find Full Text PDFCorrigendum to "Dual regulatory effects of neferine on amyloid-β and tau aggregation studied by in silico, in vitro, and lab-on-a-chip technology" [Biomed. Pharmacother. 172 (2024) 1-14/116226].
Biomed Pharmacother
December 2024
Department of Biochemistry, College of Medicine, Konyang University, 158, Gwanjeodong-ro, Seo-gu, Daejeon 35365, Republic of Korea; Research Institute for Dementia Science, Konyang University, 158, Gwanjeodong-ro, Seo-gu, Daejeon 35365, Republic of Korea. Electronic address:
Lotus Sprout Extract Induces Selective Melanosomal Autophagy and Reduces Pigmentation.
J Cosmet Dermatol
September 2024
Allergan Aesthetics, An AbbVie Company, Irvine, California, USA.
Article Synopsis
- Hyperpigmentation disorders are linked to excess melanin production, and current treatments often fall short, prompting the investigation of Lotus sprout extract (LSE) as a potential solution.
- This study explored how LSE and its active compounds, neferine and liensinine, affect melanin accumulation and found that they reduce pigmentation by enhancing autophagic degradation rather than inhibiting melanin production.
- The research indicates that LSE and its components could serve as effective treatments for hyperpigmentation by promoting melanosome degradation through autophagy, paving the way for new skin-brightening therapies.
miRNA omics reveal neferine induces apoptosis through Camediated endoplasmic reticulum stress pathway in human endometrial cancer.
Phytomedicine
November 2024
Nutrition and Bromatology Group, Analytical Chemistry and Food Science Department, University of Vigo, Vigo, 36310, Spain. Electronic address:
Article Synopsis
- Endometrial cancer is a common but serious condition in women, and while neferine (Nef), a substance from lotus seeds, shows promise for treatment, its specific anti-cancer properties are not well understood.
- The research involved testing how Nef affects cancer cells through various methods, like analyzing cell growth, apoptosis (cell death), and changes in protein expression.
- Results indicated that Nef triggers apoptosis in endometrial cancer cells by disrupting the cell cycle and influencing critical signaling pathways related to calcium levels and cancer cell survival, suggesting it could be an effective treatment for this type of cancer.
Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing.
Biomed Pharmacother
August 2024
Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, India. Electronic address:
The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process, contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation. In contrast to modern synthetic therapies, naturally occurring phytoconstituents are well-studied inhibitors of the NF-κB pathway that are now attracting increased attention in the context of diabetic wound healing because of lower toxicity, better safety and efficacy, and cost-effectiveness. This study explores recent research on phytoconstituent-based therapies and delve into their action mechanisms targeting the NF-κB pathway and potential for assisting effective healing of diabetic wounds.
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