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Trends of Mycoplasma genitalium infections in Berlin, Germany, 2017-2023.
J Glob Antimicrob Resist
December 2024
Praxis Prenzlauer Berg, Berlin, Germany.
Objectives: The cell wall-less species Mycoplasma genitalium is a sexually transmitted pathogen with strong tendency to acquire resistance. Current knowledge about trends of resistance rates and differences between the risk population of men who have sex with men (MSM) and heterosexual patients as well as about circulating genotypes in both groups is limited.
Methods: Between August 2017 and December 2023, M.
Fannyhessea vaginae and clearance of Lactobacillus iners are associated with incident non-chlamydial non-Mycoplasma genitalium urethritis in men who have sex with women.
Sex Transm Dis
December 2024
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA USA.
Background: The etiology of nongonococcal urethritis (NGU) is incompletely understood. We sought to determine if genitourinary bacterial diversity or specific taxa were associated with incident NGU.
Methods: From August 2014-July 2018, men who have sex with women attending a sexual health clinic were clinically evaluated, including Mycoplasma genitalium (MG) and Chlamydia trachomatis (CT) testing, at enrollment and six monthly visits.
[A Case of Mycoplasma genitalium Urethritis Refractory to Treatment].
Hinyokika Kiyo
November 2024
The Department of Urology, Nara Medical University.
A 28-year-old man was diagnosed with chlamydial urethritis by his previous doctor and was prescribed minocycline (MINO). The result of a urinary chlamydia polymerase chain reaction (PCR) test later confirmed to be negative. However, the patient visited our hospital because of persistent miction pain.
View Article and Find Full Text PDFImplementation of Diagnostics with Macrolide-Resistance Detection Improves Patient Treatment Outcomes in Bulgaria.
Diagnostics (Basel)
November 2024
National Center of Infectious and Parasitic Diseases (NCIPD), 1504 Sofia, Bulgaria.
The increasing prevalence of infections with macrolide-resistance, causing high azithromycin failure rates, is a major concern internationally. In response to this challenge, diagnostics that simultaneously detect and genetic markers for macrolide-resistance enable the therapy to be individually tailored, i.e.
View Article and Find Full Text PDFPhenotypic antibiotic resistance of Mycoplasma genitalium and its variation between different macrolide resistance-associated mutations.
J Antimicrob Chemother
December 2024
Department of Medical Microbiology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Objectives: Mycoplasma genitalium, a sexually transmitted bacterium, faces increasing antibiotic resistance, particularly to azithromycin. However, presence of macrolide resistance-associated mutations (MRAMs) does not evidently implicate azithromycin treatment failure. This study aimed to establish an in vitro co-culture system of M.
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