A growing body of evidence supports the use of probiotics in the treatment of several skin conditions, including wounds. Even if in vitro and in vivo studies have highlighted the pro-healing effects of some probiotic bacteria, the underlying mechanisms are still not fully defined. The current investigation aimed to determine the re-epithelialization potential of the soluble fraction from lysate of seven different probiotic strains belonging to different genera (i.e., , , and ) on in vitro physically wounded HaCaT monolayer model. The results suggested that the soluble fraction of , and promoted the re-epithelialization of scratched HaCaT monolayers, whereas those from , and significantly inhibited the process. On the other hand, showed no significant effect on in vitro wound repair. The mechanisms underlying the pro- or anti-healing properties of selected bacterial strains strictly and positively correlated with their ability to modulate nitric oxide synthase 2 (NOS2) expression and activity. Accordingly, the pre-treatment with aminoguanidine (AG), a specific inhibitor of NOS2 activity, abrogated the pro-healing effects of , and .
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| http://dx.doi.org/10.3390/biom9120756 | DOI Listing |
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