Rhabdomyolysis is a condition in which skeletal muscle breakdown causes the release of intracellular components into the bloodstream - defined as elevations in serum creatine kinase levels. The etiology of rhabdomyolysis is varied and may be the result of toxin-mediated mechanisms or metabolic derangements, or they may develop secondary to other conditions such as seizures, trauma and prolonged immobilization. In this case, we present a patient with suspected acute toxin-mediated rhabdomyolysis in the setting of trimethoprim-sulfamethoxazole (TMP-SMX) therapy for urinary tract infection. To our knowledge, this marks the fifth case report of an otherwise healthy patient diagnosed with rhabdomyolysis thought to be secondary to TMP-SMX.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861050PMC
http://dx.doi.org/10.5811/cpcem.2019.7.42688DOI Listing

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