Post Mortem Human Surrogate (PMHS) experiments are used for describing tolerance and improve safety. For nearside impacts, the United States Standard Federal Motor Vehicle Safety Standards (FMVSS-214) used PMHS tests and binary regression methods to achieve these goals. Since this promulgation, Parametric Statistical Survival Modeling (PSSM) has become a de facto standard for developing injury risk curves (IRCs). This study is focused on pelvic injuries from side impacts. The objectives are as follows. Analyze impactor-based intact PMHS tests and develop IRCs at different AIS levels using the force metric and examine the effectiveness of other force-related variables on IRCs. Impactor-driven pelvic tests conducted using whole body PMHS were selected from published studies. The dataset had 63 tests. Peak force, 3-ms clip force, and impulse were used to develop IRCs for Abbreviated Injury Scores (AIS) AIS2+ and AIS3+, i.e., groups A and B. Brier Score Metric (BSM) was used for ranking metrics. 95% confidence intervals were computed, Normalized Confidence Interval Sizes (NCIS) were determined, and quality of the IRCs were obtained. Impulse best described the underlying response of the pelvis. BSMs were the lowest for the impulse for both groups. At 10% and 50% probabilities, impulses were 71 Ns and 125 Ns for group A and 79 Ns and 160 Ns for group B; peak forces were 3.8 kN and 7.1 kN and 4 kN and 10 kN for groups A and B; and clip forces were 2.7 kN and 6.5 kN and 3.6 kN and 8.6 kN, for groups A and B. NCIS at discrete probability levels, qualities of risk curves, and individual IRCs are given. This study underscores the importance of using impulse to describe pelvis injury criteria in lateral impacts. These findings are applicable to anthropomorphic test devices, as matched pair tests are done to determine dummy-based injury criteria/injury assessment risk curves (IARCs). Although IRCs have been developed for WorldSID, it may be appropriate to use impulse-based IARCs. Because THOR is a potential device for automated vehicle environments, it may be appropriate to develop THOR-based IARCS. The present IRCs act as fundamental human-based injury criteria. These responses can also be used in human body and subsystem computational models.
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http://dx.doi.org/10.1080/15389588.2019.1682565 | DOI Listing |
J Inflamm Res
December 2024
Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Background: Surgery is the best approach to treat endometrial cancer (EC); however, there is currently a deficiency in effective scoring systems for predicting EC recurrence post-surgical resection. This study aims to develop a clinicopathological-inflammatory parameters-based nomogram to accurately predict the postoperative recurrence-free survival (RFS) rate of EC patients.
Methods: A training set containing 1068 patients and an independent validation set consisting of 537 patients were employed in this retrospective study.
J Inflamm Res
December 2024
Department of Neurology, Yancheng Third People's Hospital, Yancheng, People's Republic of China.
Objective: The aims of this study were to investigate clinical factors associated with encephalitis relapse and chronic epilepsy development, and to evaluate the effectiveness of immunotherapy on encephalitis relapse.
Methods: Patients with autoimmune encephalitis diagnosed as positive for neuronal surface antibodies in five general hospitals were included. A minimum 12-month follow-up period was conducted, and binary logistic regression analysis was used to identify predictors of encephalitis relapse and chronic epilepsy development.
Front Cardiovasc Med
December 2024
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Background: Coronary artery bypass grafting (CABG) surgery has been a widely accepted method for treating coronary artery disease. However, its postoperative complications can have a significant effect on long-term patient outcomes. A retrospective study was conducted to identify before and after surgery that contribute to postoperative stroke in patients undergoing CABG, and to develop predictive models and recommendations for single-factor thresholds.
View Article and Find Full Text PDFFront Cardiovasc Med
December 2024
Department of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objective: This study compared the value of different systemic immune-inflammatory markers for evaluating coronary collateralization (CC) in patients with type 2 diabetes mellitus (T2DM) and chronic total occlusion (CTO).
Methods: Systemic immune-inflammation index (SII), systemic inflammation response index (SIRI) and pan-immune-inflammation value (PIV) were calculated at admission in 1409 T2DM patients with CTO. The degree of coronary collaterals was estimated using the Rentrop scoring system and categorized into poor (Rentrop score 0 or 1) or good (Rentrop score 2 or 3) CC.
Front Cardiovasc Med
December 2024
Department of Cardiovascular Medicine, Tacheng People's Hospital, Tacheng, China.
Objective: To analyze the risk factors for coronary heart disease (CHD) in patients hospitalized in general hospitals in the Tacheng Prefecture, Xinjiang, and to construct and verify the nomogram prediction model for the risk of CHD.
Methods: From June 2022 to June 2023, 489 CHD patients (CHD group) and 520 non-CHD individuals (control group) in Tacheng, Xinjiang, were retrospectively selected. Using a 7:3 ratio, patients were divided into a training group (706 cases) and a validation group (303 cases).
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