AI Article Synopsis
- Conditional mutagenesis and fate mapping enhance our understanding of how specific cells contribute to diseases and their communication in animal models.
- The study compared two types of transgenic mice (Cx cr1 and Sall1) to better understand the brain macrophage population using new technological advances.
- The research emphasizes the importance of accurately defining Cre recombinase expression and understanding the strengths and weaknesses of these models when applied in experiments.
Article Abstract
Conditional mutagenesis and fate mapping have contributed considerably to our understanding of physiology and pathology. Specifically, Cre recombinase-based approaches allow the definition of cell type-specific contributions to disease development and of inter-cellular communication circuits in respective animal models. Here we compared Cx cr1 and Sall1 transgenic mice and their use to decipher the brain macrophage compartment as a showcase to discuss recent technological advances. Specifically, we highlight the need to define the accuracy of Cre recombinase expression, as well as strengths and pitfalls of these particular systems that should be taken into consideration when applying these models.
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| http://dx.doi.org/10.1002/eji.201948342 | DOI Listing |
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