AI Article Synopsis
- The fluorescence of water-soluble β-(1,3-1,6)-d-glucan-complexed porphyrin derivatives was low due to self-quenching effects.
- The β-1,3-glucan-complexed tetra(aminophenyl)porphyrin demonstrated the ability to switch from an 'off-state' to an 'on-state' fluorescence upon being taken up by cells.
- This internalized complex exhibited significant photodynamic activity against HeLa cells when exposed to long-wavelength photoirradiation.
Article Abstract
Fluorescence intensities of water-soluble β-(1,3-1,6)-d-glucan (β-1,3-glucan)-complexed porphyrin derivatives were very weak as a result of self-quenching. However, β-1,3-glucan-complexed tetra(aminophenyl)porphyrin exhibited 'off-state' to 'on-state' fluorescence switching activity by intracellular uptake. Furthermore, the internalised complex showed a high level of photodynamic activity toward HeLa cells under photoirradiation at long wavelengths.
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| http://dx.doi.org/10.1039/c9pp00208a | DOI Listing |
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