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CRISPR/Cas9-induced knockout of tumor necrosis factor-alpha-type I augments viral infection in zebrafish.
Fish Shellfish Immunol
December 2024
Department of Marine Life Sciences & Center for Genomic Selection in Korean Aquaculture, Jeju National University, Jeju 63243, Republic of Korea; Marine Life Research Institute, Gidang Marine Research Institute, Jeju National University, Jeju 63333, Republic of Korea. Electronic address:
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic cytokine with critical roles in inflammation, cell survival, and defense. As a member of the TNF superfamily, it exerts its effects by binding to transmembrane receptors and triggering various downstream signaling pathways. Although TNF-α's involvement in antiviral responses in mammals is well-established, its role in teleost remains poorly understood.
View Article and Find Full Text PDFSilencing Osa-miR827 via CRISPR/Cas9 protects rice against the blast fungus Magnaporthe oryzae.
Plant Mol Biol
September 2024
Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB. Campus Universitat Autònoma de Barcelona (UAB), Bellaterra (Cerdanyola del Vallés), 08193, Barcelona, Spain.
MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression at the post-transcriptional level. In plants, miRNAs participate in diverse developmental processes and adaptive responses to biotic and abiotic stress. MiR827 has long been recognized to be involved in plant responses to phosphate starvation.
View Article and Find Full Text PDFDNA damage drives antigen diversification through mosaic Variant Surface Glycoprotein (VSG) formation in .
bioRxiv
August 2024
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Antigenic variation, using large genomic repertoires of antigen-encoding genes, allows pathogens to evade host antibody. Many pathogens, including the African trypanosome , extend their antigenic repertoire through genomic diversification. While evidence suggests that depends on the generation of new variant surface glycoprotein (VSG) genes to maintain a chronic infection, a lack of experimentally tractable tools for studying this process has obscured its underlying mechanisms.
View Article and Find Full Text PDFCRISPR/Cas9-induced knockout of an amino acid permease gene (AAP6) reduced Arabidopsis thaliana susceptibility to Meloidogyne incognita.
BMC Plant Biol
June 2024
Division of Plant Physiology, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India.
Background: Plant-parasitic root-knot nematode (Meloidogyne incognita) causes global yield loss in agri- and horticultural crops. Nematode management options rely on chemical method. However, only a handful of nematicides are commercially available.
View Article and Find Full Text PDFCRISPR-Cas9-Induced Gene Editing in Primary Human Monocytes.
Methods Mol Biol
April 2024
Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.
Monocytes play important and diverse roles in both homeostatic and inflammatory immune responses. The CRISPR-Cas9 system in lentiviral vectors has been widely used to manipulate specific genes of immortal monocyte cell lines to study monocyte functions. However, human primary monocytes are refractory to this method with low gene knockout (KO) efficiency.
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