AI Article Synopsis
- Y-labelled albumin microspheres (AMS) were created by optimizing their preparation process to enhance stability.
- Three formulations were tested, showing that the timing of adding the Y radionuclide and DTPA chelator affected the stability of the microspheres.
- DTPA effectively binds the Y radionuclide to albumin, and the AMS that were labelled before stabilization demonstrated strong stability for potential use in selective internal radiation therapy.
Article Abstract
Biologically stable Y-labelled albumin microspheres (AMS) were developed by optimizing the process of their preparation. Three formulations of Y-AMS were initially prepared with high radiolabelling yield but depending on the step when the radionuclide Y and DTPA chelator were added, radiolabelled microspheres with different in vitro and in vivo stability were obtained. DTPA was proved as a useful chelating agent that tightly links radionuclide Y to albumin. Also, AMS radiolabelled via DTPA during preparation and before microspheres stabilization, showed significant in vitro and in vivo stability ready for the potential use in selective internal radiation therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.apradiso.2019.108984 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!