In vivo 5-HT and 5-HT receptor availability in antipsychotic treated schizophrenia patients vs. unmedicated healthy humans measured with [C]GSK215083 PET.

While 5-HT receptor is a potential therapeutic target for cognitive impairment in schizophrenia (SCZ), in vivo 5-HT receptor availability following antipsychotic treatment has not been examined to-date. We examined the availability of 5-HT and 5-HT receptors following treatment with olanzapine, risperidone, aripiprazole and quetiapine in male patients with SCZ vs unmedicated age-matched healthy male controls (HC) using positron emission tomography (PET) imaging with [C]GSK215083. [C]GSK215083 has been shown to have selectivity for 5-HT in the striatum and 5-HT in the cortex. Patients with SCZ (n = 9) were scanned with [C]GSK215083 on HR+ PET scanner at presumed steady-state trough and peak serum levels following 7 days of confirmed inpatient antipsychotic treatment. Time-activity curves in regions-of-interest were fitted with multilinear analysis-1 (MA1). Regional nondisplaceable binding potential (BP) values were calculated using cerebellum as the reference region and corrected for partial volume effects. Compared to HCs (n = 9), olanzapine was associated with significantly lower BP (range: 53%-95%) in ventral striatum, putamen, caudate and frontal cortex at both trough and peak scans. Risperidone was associated with significantly lower BP in frontal cortex at both trough and peak scans. The study provides preliminary evidence that treatment with different second-generation antipsychotics results in differing profiles of 5-HT and 5-HT availability.