AI Article Synopsis
- The study focuses on the effects of Na-alginate treatment in protecting bone marrow cells from radiation damage caused by 226Radium (226Ra) exposure in mice.
- At lower exposure levels (4-8 micronCi/kg), there’s no noticeable harm to the stem cells, but significant damage occurs at 9.0 micronCi/kg and above in untreated mice.
- Na-alginate treatment appears to mitigate the damage by enhancing the removal of 226Ra from bone surfaces, thereby reducing the radiation dose affecting marrow stem cells.
Article Abstract
226Ra toxicity studies form the experimental basis for the estimation of radiation risk from internal emitters in man. We investigated whether treatment with Na-alginate is able to protect haemopoietic bone marrow cells against alpha-irradiation from 226Ra contamination. Doses from 4 to 14 micronCi/kg were injected intraperitoneally in mice 12 days before the start of the treatment. Damage to marrow stem cells was assessed by the exogene clonal spleen technique. Collection of marrow cells by two methods was compared. In the lower dose groups no influence on stem cell survival is noticed. but from 9.0 micronCi/kg a decrease in the number of surviving stem cells is observable in non treated animals. while in animals treated with Na-alginate fewer stem cells are damaged. These preliminary data agree with the hypothesis that Na-alginate stimulates removal of 226Ra mainly from the endosteal bone surfaces, reducing the local 226 Ra dose which accounts for damage to marrow stem cells within the range of alpha-rays at the endosteal surfaces.
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| http://dx.doi.org/10.1080/09553007914551161 | DOI Listing |
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