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Case report: Ectopic production of intact parathyroid hormone (iPTH) by malignoma mimicking primary hyperparathyroidism.
Front Oncol
December 2024
Department of Nephrology, St. Georg Hospital, Leipzig, Germany.
Background: Malignant hypercalcemia is usually caused by osteolytic processes of metastases, production of parathormone-related peptide, or secretion of 1,25-dihydroxyvitamin D. Ectopic PTH (parathyroid hormone) production by malignancy is very unusual.
Methods: Case report and review of the literature.
Uncovering Hypercalcemia of Malignancy Following Parathyroidectomy for Hyperparathyroidism.
JCEM Case Rep
December 2024
Department of Nephrology, Permian Basin Kidney Center, Odessa, TX 79761, USA.
Hypercalcemia is a common complication of malignancy, often attributed to elevated PTH-related protein levels mimicking the effects of PTH and promoting bone resorption. We present the case of a 67-year-old Hispanic female with a history of hypertension, type 2 diabetes mellitus, hyperlipidemia, and chronic kidney disease, who initially underwent parathyroidectomy for suspected primary hyperparathyroidism resulting from persistent hypercalcemia. Despite surgery, the patient continued to experience hypercalcemia and was subsequently diagnosed with diffuse large B-cell lymphoma with hypercalcemia as a rare but life-threatening complication.
View Article and Find Full Text PDFNecrotizing Fasciitis Mimicking Interstitial Cystitis: An Atypical Clinical Presentation.
Cureus
September 2024
Family Medicine, Ballad Health, Abingdon, USA.
Article Synopsis
- Necrotizing fasciitis is a dangerous, life-threatening infection that can be hard to diagnose due to its vague symptoms, making early detection and treatment critical to survival.
- A 60-year-old woman initially presented with urinary tract infection symptoms but quickly deteriorated, leading to a diagnosis of necrotizing fasciitis after severe abdominal pain and fever prompted further investigation.
- This case emphasizes the need for healthcare professionals to stay alert and consider serious underlying issues, even if symptoms seem minor, to prevent misdiagnosis and ensure prompt treatment.
Cancer and hidradenitis suppurativa.
Clin Dermatol
December 2024
DermSurgery Associates, Sugar Land, Texas, USA.
Article Synopsis
- * Factors like smoking, prolonged lesions, and certain treatments (like TNF-alpha inhibitors) may increase the risk of developing squamous cell carcinoma in these patients.
- * There is a need for careful monitoring of new or rapidly changing lesions in hidradenitis suppurativa patients, as they can mimic or hide underlying cancers, necessitating prompt medical evaluation.
Incidentally detected follicular thyroid carcinoma mimicking parathyroid adenoma on Tc-99m MIBI scan: A case report.
Medicine (Baltimore)
May 2024
Department of Nuclear Medicine, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Cyclotron Research Center, Molecular Imaging and Therapeutic Medicine Research Center, Jeonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, Republic of Korea.
Rationale: Primary hyperparathyroidism, though relatively prevalent among endocrine disorders, affecting 1% of the general population, often presents diagnostic challenges. Given its potential to precipitate severe complications including nephrolithiasis and fractures, timely diagnosis, and effective management are crucial.
Patient Concerns: A 38-year-old woman with hypercalcemia was referred to the Department of Nuclear Medicine for a Tc-99m MIBI scan.
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