Aims/introduction: To assess the effect of dulaglutide (DU) 1.5/0.75 mg in comparison with glimepiride (GLIM) or insulin glargine (GLAR) on the composite end-point in Chinese type 2 diabetes patients.
Materials And Methods: Post-hoc analyses of two randomized phase III trials (NCT01644500 and NCT01648582) were carried out using Fisher's exact test. The primary composite end-point was the number of patients reaching glycated hemoglobin (HbA1c) <7.0%, without weight gain and hypoglycemia. Secondary composite end-points included the number of patients reaching HbA1c <7.0% without weight gain and HbA1c <7.0% without hypoglycemia.
Results: Data of 1,147 Chinese type 2 diabetes patients were analyzed (NCT01644500 = 556; NCT01648582 = 591). In each analyzed trial, 40-48% of patients received DU (1.5 mg), 30-39% of patients received DU (0.75 mg) and 15-20% of patients on active comparators (GLIM/GLAR) reached the primary composite end-point at week 26 (P < 0.001 for DU vs GLIM/GLAR). At 52 weeks, 26% of patients that received DU (1.5 mg), 23% of patients that received DU (0.75 mg) and 7% of patients that received GLAR attained the primary composite end-point (P < 0.001 for DU vs GLAR). A similar trend of results was found for secondary composite end-points.
Conclusions: Dulaglutide is found to be an effective therapeutic alternative for Chinese type 2 diabetes patients. Compared with GLIM/GLAR, significantly greater proportions of patients on DU attained the HbA1c target of <7.0% without weight gain or hypoglycemia.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232276 | PMC |
| http://dx.doi.org/10.1111/jdi.13187 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Navigating the challenges of engineering composite specialized metabolite pathways in plants.
Plant J
March 2025
Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Plants are a valuable source of diverse specialized metabolites with numerous applications. However, these compounds are often produced in limited quantities, particularly under unfavorable ecological conditions. To achieve sufficient levels of target metabolites, alternative strategies such as pathway engineering in heterologous systems like microbes (e.
View Article and Find Full Text PDFMechanically Robust Mesoporous UiO-66-NH/Nanofibrous Aerogel for Organophosphonates Detoxification.
Adv Sci (Weinh)
March 2025
Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC, 27695, USA.
There is a critical need for novel composite materials for high-performance chemical filtration and detoxification of organophosphonates (OPs) and other harmful compounds found in nerve agents, pesticides, and industrial processes. In this work, rapid hydrolysis of OPs using high-surface-area zirconium-based MOF-aerogel composites is demonstrated. Using a unique surfactant-templated solvothermal synthesis method, mesoporous UiO-66-NH grown on the fibers within a polyacrylonitrile (PAN)/polyvinylpyrrolidone (PVP) nanofibrous sponge can produce a 3D MOF-polymer matrix with a specific surface area of up to 900 m g -almost 2X larger than the highest previously reported values while maintaining robust mechanical integrity.
View Article and Find Full Text PDFVM-UNet++ research on crack image segmentation based on improved VM-UNet.
Sci Rep
March 2025
School of Transportation and Logistics, East China Jiaotong University, Nanchang, 330013, China.
Cracks are common defects in physical structures, and if not detected and addressed in a timely manner, they can pose a severe threat to the overall safety of the structure. In recent years, with advancements in deep learning, particularly the widespread use of Convolutional Neural Networks (CNNs) and Transformers, significant breakthroughs have been made in the field of crack detection. However, CNNs still face limitations in capturing global information due to their local receptive fields when processing images.
View Article and Find Full Text PDFDevelopment of moringa seed powder-modified slag geopolymers for enhanced mechanical properties and effective dye removal.
Sci Rep
March 2025
Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, 11757, Egypt.
Crystal violet (CV), a widely used dye in paints and textiles, poses a significant environmental threat due to its non-biodegradable nature. A modified slag-based geopolymer has been developed to address this issue by incorporating raw moringa seed powder (MSP), an agricultural waste. The geopolymers (SM1, SM2, and SM3) were created by adding different percentages of MSP (0.
View Article and Find Full Text PDFPulmonary complications associated with sugammadex or neostigmine in patients recovering from advanced diagnostic or interventional bronchoscopy: a retrospective two-centre analysis.
Br J Anaesth
March 2025
Center for Outcomes Research, and Department of Anesthesiology, UTHealth, Houston, TX, USA.
Background: Many diagnostic and interventional procedures are performed in bronchoscopy suites in high-risk patients. Minor impairment in respiratory muscle function caused by incomplete reversal of neuromuscular block can contribute to postoperative pulmonary complications (PPCs). We assessed whether there are fewer serious PPCs after diagnostic or therapeutic bronchoscopy when neuromuscular block is reversed with sugammadex rather than neostigmine.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!