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The Increasing Issue of Vancomycin-Resistant Enterococci and the Bacteriocin Solution. | LitMetric

The Increasing Issue of Vancomycin-Resistant Enterococci and the Bacteriocin Solution.

Probiotics Antimicrob Proteins

Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P.O. Box 5003, 1432, Ås, Norway.

Published: September 2020

Enterococci are commensals of human and other animals' gastrointestinal tracts. Only making up a small part of the microbiota, they have not played a significant role in research, until the 1980s. Although the exact year is variable according to different geographical areas, this was the decade when vancomycin-resistant enterococci (VRE) were discovered and since then their role as causative agents of human infections has increased. Enterococcus faecium is on the WHO's list of "bacteria for which new antibiotics are urgently needed," and with no new antibiotics in development, the situation is desperate. In this review, different aspects of VRE are outlined, including the mortality caused by VRE, antibiotic resistance profiles, animal-modeling efforts, and virulence. In addition, the limitations of current antibiotic treatments for VRE and prospective new treatments, such as bacteriocins, are reviewed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613153PMC
http://dx.doi.org/10.1007/s12602-019-09618-6DOI Listing

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