Purpose: The aim of this study is to investigate the effect of wood dust on nasal mucociliary clearance time in wood industry workers. Moreover, the correlation between duration of exposure to wood dust and nasal mucociliary clearance time will be evaluated.
Methods: A total of 50 male subjects were included in the study. All of the subjects were non-smokers. Nasal mucociliary clearance time of 25 wood industry workers was measured with saccharine method and compared with the results of 25 age-matched control group. Also, the correlation between nasal mucociliary clearance time and duration of exposure to wood dust in woodworkers was evaluated.
Results: The mean mucociliary clearance time in control group and wood industry workers was 12.28 ± 1.98 and 16.72 ± 2.71, respectively. The mean mucociliary clearance time in wood industry workers was significantly longer than control group (p < 0.0001). Also,there was positive correlation between duration of exposure to wood dust and nasal mucociliary clearance time in wood industry workers (r = 0.879, p < 0.0001).
Conclusion: The clinicians must remember that mucociliary clearance time in wood industry workers is prolonged. So the wood industry workers must be followed up more closely for sinonasal infections and respiratory tract diseases.
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http://dx.doi.org/10.1007/s00405-019-05729-6 | DOI Listing |
Biol Pharm Bull
December 2024
Laboratory of Clinical and Translational Physiology, Kyoto Pharmaceutical University.
Mucociliary clearance (MCC) is a host defense mechanism of the respiratory system. Beating cilia plays a crucial role in the MCC process and ciliary beat frequency (CBF) is activated by several factors including elevations of the intracellular cAMP concentration ([cAMP]), intracellular Ca concentration ([Ca]), and intracellular pH (pH). In this study, we investigated whether an artichoke-extracted component cynaropicrin could be a beneficial compound for improving MCC.
View Article and Find Full Text PDFBasic Clin Androl
December 2024
RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic.
Background: Primary ciliary dyskinesia (PCD) is a heterogenous disease caused by mutations of miscellaneous genes which physiologically play an important role in proper structure and/or function of various cellular cilia including sperm flagella. Besides male infertility, the typical phenotypes, based on decreased mucociliary clearance, are lifelong respiratory issues, i.e.
View Article and Find Full Text PDFPolymers (Basel)
December 2024
College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
The aim of this study was to develop a thermosensitive mucoadhesive (MA) in situ nasal gel for sumatriptan. A 3D response surface methodology (Design of Expert version 11) was employed to formulate nine different formulations. The Pluronic F-127 concentration (X1) and chitosan concentration (X2) were selected as independent factors.
View Article and Find Full Text PDFCells
December 2024
Department of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA.
Human immunodeficiency virus type-1 (HIV-1) associated comorbidities account for the majority of poor health outcomes in people living with HIV (PLWH) in the era of antiretroviral therapy. Lung-related comorbidities such as chronic obstructive pulmonary disease (COPD) and bacterial pneumonia are primarily responsible for increased morbidity and mortality in PLWH, even when compensated for smoking. Smokers and COPD patients demonstrate cilia shortening, attenuated ciliary beat frequency (CBF), dysfunctional ciliated cells along with goblet cell hyperplasia, and mucus hypersecretion.
View Article and Find Full Text PDFRhinology
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
In our recent study, increased viscosity, delayed mucociliary clearance as well as hyposensitivity/dysesthesia of the nasopharynx seemed to play a relevant role in the pathophysiology of postnasal drip (PND) (1). Earlier concepts of PND, regarding an increased volume of secretions and atopy, do not seem to hold true since our latest analyses showed no significant difference between cases and controls (1). However, to this day its therapy is debated and the evidence for an effective treatment of PND is lacking so far.
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