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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935842 | PMC |
| http://dx.doi.org/10.1212/NXI.0000000000000641 | DOI Listing |
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Spatial and temporal analysis of West Nile virus infection in mosquito and human populations based on arboviral detection testing data.
Sci Rep
December 2024
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
West Nile virus (WNV) is a mosquito-borne zoonotic flavivirus which often causes asymptomatic infection in humans but may develop into a deadly neuroinvasive disease. In this study, we aimed to investigate variables potentially associated with human WNV infection using human and mosquito WNV surveillance and monitoring datasets, established over 20 years, from 2003 to 2022, across the province of Ontario, Canada. We combined climatic and geographic data, mosquito surveillance data (n = 3010 sites), blood donation arboviral detection testing data in the human population, and demographic and socio-economic data from Canadian population censuses.
View Article and Find Full Text PDFEvaluation of Protocols for DNA Extraction from Individual to Assess Pyrethroid Resistance Using Genotyping Real-Time Polymerase Chain Reaction.
Methods Protoc
December 2024
General Diagnostic Department, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana "M. Aleandri", 00178 Rome, Italy.
is a major vector of pathogens, including West Nile and Usutu viruses, that poses a significant public health risk. Monitoring pyrethroid resistance in mosquito populations is essential for effective vector control. This study aims to evaluate four DNA extraction protocols-QIAsymphony, DNAzol Direct reagent, PrepMan Ultra Sample Preparation Reagent (USPR), and Chelex 100-to identify an optimal method to extract DNA from individual , as part of a high-throughput surveillance of pyrethroid resistance using Real-Time Genotyping PCR.
View Article and Find Full Text PDFObjectives: Arboviruses pose a significant global health challenge. This study investigated the seroprevalence of major human arboviral infections, including yellow fever (YFV), dengue (DENV), Crimean-Congo hemorrhagic fever (CCHF), Rift Valley fever (RVF), West Nile virus (WNV), and chikungunya (CHIK), in Darfur region from September to December 2018. ELISA-IgM was used to detect antibodies.
View Article and Find Full Text PDFCCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis.
J Neuroinflammation
December 2024
Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Central nervous system (CNS) resident memory CD8 T cells (T) that express IFN-γ contribute to neurodegenerative processes, including synapse loss, leading to memory impairment. Here, we show that CCR2 signaling in CD8 T that persist within the hippocampus after recovery from CNS infection with West Nile virus (WNV) significantly prevents the development of memory impairments. Using CCR2-deficient mice, we determined that CCR2 expression is not essential for CNS T cell recruitment or virologic control during acute WNV infection.
View Article and Find Full Text PDFModeling the lagged and nonlinear effects of weather conditions on abundance of Culex tarsalis mosquitoes in Saskatchewan, Western Canada using a bi-dimensional distributed lag nonlinear model.
Acta Trop
December 2024
Department of Geography and Planning, University of Saskatchewan, 117 Science Place, Saskatoon, Saskatchewan, S7N 5C8, Canada; Global Institute for Water Security, University of Saskatchewan, Saskatoon, Canada. Electronic address:
Article Synopsis
- The study examines the impact of weather conditions on the abundance of Culex tarsalis mosquitoes in Saskatchewan, Canada, from 2010 to 2021, highlighting a public health concern regarding West Nile Virus (WNV) transmission.
- Researchers found that Cx. tarsalis mosquitoes peaked in abundance during July and August, with temperature and rainfall significantly influencing their population dynamics; specifically, moderate temperatures promoted abundance while high rainfall and wind reduced it.
- The analysis identified both nonlinear and linear relationships between weather variables and mosquito abundance, providing valuable insights for public health officials to optimize vector control measures during peak mosquito activity periods.
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