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Distribution and neurochemical characterisation of neurons containing neuregulin 1 in the enteric nervous system within the porcine small intestine.
J Vet Res
December 2024
Institute of Biology, College of Natural Sciences, University of Rzeszów, 35-310 Rzeszów, Poland.
Introduction: The enteric nervous system (ENS) in the wall of the gastrointestinal tract is complex and comprises many neurons, which are differentiated in terms of structure, function and neurochemistry. Neuregulin 1 (NRG 1) is one of the neuronal factors synthesised in the ENS about the distribution and functions of which relatively little is known. The present study is the first description of the distribution of NRG 1 in the ENS in various segments of the porcine small intestine.
View Article and Find Full Text PDFAnalysis on the pathogenesis and treatment progress of NRG1 fusion-positive non-small cell lung cancer.
Front Oncol
June 2024
Oncology Department of Integrated Traditional Chinese and Western Medicine, Shenyang Chest Hospital & Tenth People's Hospital, Shenyang, Liaoning, China.
Lung cancer persistently leads as the primary cause of morbidity and mortality among malignancies. A notable increase in the prevalence of lung adenocarcinoma has become evident in recent years. Although targeted therapies have shown in treating certain subsets of non-small cell lung cancers (NSCLC), a significant proportion of patients still face suboptimal therapeutic outcomes.
View Article and Find Full Text PDFMutations in aristaless-related homeobox ( ) are associated with neurodevelopmental disorders including developmental epilepsies, intellectual disabilities, and autism spectrum disorders, with or without brain malformations. Aspects of these disorders have been linked to abnormal cortical interneuron (cIN) development and function. To further understand ARX's role in cIN development, multiple mutant mouse lines were interrogated.
View Article and Find Full Text PDFNeuregulin 1 (NRG1) and its receptors in the enteric nervous system and other parts of the gastrointestinal wall.
Histol Histopathol
September 2024
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Neuregulin 1 (NRG1) belonging to the transmembrane growth factors family is widespread in living organisms. It acts through ErbB family receptors and first of all takes part in embryogenesis, as well as in developmental, regenerative and adaptive processes occurring in various internal organs and systems. It is known that NRG1 and its receptors are present in various parts of the gastrointestinal (GI) tract.
View Article and Find Full Text PDFHost-Specific and Homologous Pairs of Effectors Unveil Novel Stromule Induction Factors.
Mol Plant Microbe Interact
March 2024
Chemistry, Biochemistry, and Physics Department, Université du Québec à Trois-Rivières, Trois-Rivières, G8Z 4M3, Canada.
The poplar rust fungus is part of one of the most devastating group of fungi (Pucciniales) and causes important economic losses to the poplar industry. Because is a heteroecious obligate biotroph, its spread depends on its ability to carry out its reproductive cycle through larch and then poplar parasitism. Genomic approaches have identified more than 1,000 candidate secreted effector proteins (CSEPs) from the predicted secretome of that are potentially implicated in the infection process.
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