AI Article Synopsis
- The study aimed to validate two new indexes, interhemispheric signal propagation (ISP) and interhemispheric balance (IHB), using a combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) in healthy volunteers.
- Over 50 participants were tested, with evaluations repeated after three weeks to ensure the reliability of ISP and IHB measures, while also checking their correlation with traditional interhemispheric inhibition (IHI).
- Results indicated that ISP and IHB showed high reproducibility, strong test-retest reliability, and were linearly correlated with IHI, suggesting their potential importance in studying brain dynamics, especially in clinical settings where standard measures like motor-evoked potentials (
Article Abstract
Objective: To validate two indexes of interhemispheric signal propagation (ISP) and balance (IHB) by combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG).
Methods: We used TMS-EEG to non-invasively stimulate the two hemispheres of 50 healthy volunteers and measured interhemispheric dynamics in terms of ISP and IHB. We repeated our evaluation after three weeks to assess the reliability of our indexes. We also tested whether our TMS-EEG measures were correlated with traditional interhemispheric inhibition (IHI), as measured with motor-evoked potentials (MEPs).
Results: Our main results showed that ISP and IHB (1) have a high reproducibility among all the participants tested; (2) have a high test-retest reliability (3) are linearly correlated with IHI, as measured with MEPs.
Conclusions: The main contribution of this study lies in the proposal of new TMS-EEG cortical measures of interhemispheric dynamics and in their validation in terms of intra- and inter-subject reliability. We also provide the first demonstration of the correlation between ISP and IHI.
Significance: Our results are relevant for the investigation of interhemispheric dynamics in clinical populations where MEPs are not reliable.
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| http://dx.doi.org/10.1016/j.clinph.2019.09.013 | DOI Listing |
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