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State-of-the-Art Liver Cancer Organoids: Modeling Cancer Stem Cell Heterogeneity for Personalized Treatment.
BioDrugs
January 2025
Orsay-Vallée Campus, Paris-Saclay University, Gif-sur-Yvette, France.
Liver cancer poses a global health challenge with limited therapeutic options. Notably, the limited success of current therapies in patients with primary liver cancers (PLCs) may be attributed to the high heterogeneity of both hepatocellular carcinoma (HCCs) and intrahepatic cholangiocarcinoma (iCCAs). This heterogeneity evolves over time as tumor-initiating stem cells, or cancer stem cells (CSCs), undergo (epi)genetic alterations or encounter microenvironmental changes within the tumor microenvironment.
View Article and Find Full Text PDFUpdated Review of Proximal Gastrectomy for Gastric Cancer or Cancer of the Gastroesophageal Junction.
J Gastric Cancer
January 2025
Department of Gastroenterological Surgery, Cancer Institute Hospital Ariake, Tokyo, Japan.
Proximal gastrectomy (PG) has reemerged as a viable surgical option for managing proximal gastric cancer and gastroesophageal junction cancer, particularly for early-stage tumors, offering potential advantages over total gastrectomy (TG). This review examines the evolution of PG, emphasizing surgical techniques and outcomes. Although PG was initially abandoned due to postoperative complications such as reflux esophagitis, advances in reconstruction methods, such as the double-flap technique and double-tract reconstruction, have significantly improved patient quality of life and reduced complications.
View Article and Find Full Text PDFOptimizing work in community pharmacy: What preferences do community pharmacists and pharmacy technicians have for a better allocation of daily activities?
Explor Res Clin Soc Pharm
March 2025
Equipe ThEMAS, Univ. Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC-IMAG, 38000 Grenoble, France.
Objective: Pharmacy work encompasses two main streams. These are logistic flow (the supply and distribution of healthcare products) and pharmaceutical flow (the dispensing and provision of pharmacy services). The pharmaceutical flow has increased significantly with the introduction of reimbursed services such as Rapid Diagnostic Tests, chronic disease screening, minor ailment prescriptions, vaccine prescription and administration, and medication reviews.
View Article and Find Full Text PDFDynamics and triggers of misinformation on vaccines.
PLoS One
January 2025
Centro Ricerche Enrico Fermi, Rome, Italy.
The Covid-19 pandemic has sparked renewed attention to the risks of online misinformation, emphasizing its impact on individuals' quality of life through the spread of health-related myths and misconceptions. In this study, we analyze 6 years (2016-2021) of Italian vaccine debate across diverse social media platforms (Facebook, Instagram, Twitter, YouTube), encompassing all major news sources-both questionable and reliable. We first use the symbolic transfer entropy analysis of news production time-series to dynamically determine which category of sources, questionable or reliable, causally drives the agenda on vaccines.
View Article and Find Full Text PDFLived experience of pilonidal sinus disease: Systematic review and meta-ethnography.
Colorectal Dis
January 2025
Department of Colorectal Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Aim: Pilonidal sinus disease (PSD) poses significant treatment challenges due to a lack of consensus on the diverse range of surgical approaches routinely employed, prompting a renewed focus on the patient experience. The aim of this study was to explore the lived experience of patients with PSD to better inform future person-centred treatment.
Method: A systematic review was performed to identify papers reporting qualitative studies on the lived experience of PSD.
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