Purpose: To compare the efficacy of cleaning of rigid contact lenses using two care solutions with and without rubbing.
Methods: A masked randomised trial was conducted. The cleaning efficacy of two solutions recommended for rigid contact lenses, a one-step hydrogen peroxide solution (HP) and a povidone iodine-based solution (PI), were evaluated on 64 unworn orthokeratology (ortho-k) lenses subsequent to cleaning with rubbing (R) with a surfactant cleaner or without rubbing (NR). Either mascara or hand cream was applied as a contaminant to the lenses to simulate stubborn and loosely bounded deposits, respectively. For each type of deposit, the lenses were randomly assigned to four cleaning treatments: R with HP, NR with HP, R with PI, and NR with PI (n = 8 for each group). Each lens surface was assessed on site by a masked examiner under a low-magnification slit-lamp and with photo-documentation. Lenses were graded according to the deposit coverage area using a pre-set five-point scale [0 (<20% coverage) - 4 (>80% coverage)].
Results: For stubborn deposits (mascara), NR failed to remove deposits from 94% of lenses, whilst R removed more than 80% of deposits from 63% of the lenses. For oily deposits, 25% of NR lenses had >80% coverage, whilst only one R lens had 60-80% coverage, with 19% having 40-60% coverage, and 38% with either 20-40% or <20%. Rubbing improved lens cleanliness for both types of deposits, but only reached statistical significance for the stubborn deposit group. There were no significant differences between the solutions.
Conclusion: Not Rubbing and using either HP or PI solutions, is not effective in removing stubborn deposits from ortho-k lenses. It is essential to rub lenses when cleaning rigid lenses to ensure optimal lens hygiene for ocular health, especially as rigid gas permeable (RGP) lenses are intended to be reused for at least a year before replacement. Rubbing with a daily cleaner should be included in the instructions for use of the solutions tested for rigid lenses and practitioners should be encouraged to emphasise the importance of rubbing in lens care.
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http://dx.doi.org/10.1111/opo.12655 | DOI Listing |
J Phys Chem B
January 2025
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Computationally designed 29-residue peptides yield tetra-α-helical bundles with symmetry. The "bundlemers" can be bifunctionally linked via thiol-maleimide cross-links at their N-termini, yielding supramolecular polymers with unusually large, micrometer-scale persistence lengths. To provide a molecularly resolved understanding of these systems, all-atom molecular modeling and simulations of linked bundlemers in explicit solvent are presented.
View Article and Find Full Text PDFPRX Life
June 2024
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Biomolecular condensates are dynamic intracellular entities defined by their sequence- and composition-encoded material properties. During aging, these properties can change dramatically, potentially leading to pathological solidlike states, the mechanisms of which remain poorly understood. Recent experiments reveal that the aging of condensates involves a complex interplay of solvent depletion, strengthening of sticker links, and the formation of rigid structural segments such as beta fibrils.
View Article and Find Full Text PDFOphthalmic Physiol Opt
January 2025
Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, Queensland, Australia.
Introduction: Tear exchange during contact lens wear is essential for ocular surface integrity, facilitating debris removal, and maintaining corneal metabolism. Fluorophotometry and fluorogram methods are typically used to measure tear exchange, which require hardware modifications to a slit lamp biomicroscope. This manuscript introduces an alternative method using a corneoscleral profilometer, the Eye Surface Profiler (ESP), to quantify tear exchange during corneal and scleral rigid lens wear by assessing fluorescence intensity changes over time.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
System-level wearable electronics require to be flexible to ensure conformal contact with the skin, but they also need to integrate rigid and bulky functional components to achieve system-level functionality. As one of integration methods, folding integration offers simplified processing and enhanced functionality through rigid-soft region separation, but so far, it has mainly been applied to modality of electrical sensing and stimulation. This paper introduces a vialess heterogeneous skin patch with multi modalities that separates the soft region and strain-robust region through folded structure.
View Article and Find Full Text PDFCornea
January 2025
Department of Ophthalmology, Rothschild Foundation, Paris, France; and.
Purpose: The purpose of this study was to investigate the effect of hypoxia and hypobaric conditions on refraction and central corneal thickness on healthy corneas during an ascent without oxygen supplementation above 7000 m (23 000 ft).
Methods: Twelve multinational mountaineers were included in a prospective observational cohort study during an expedition to the Korzhenevskoi Peak (7105 m). The two patients excluded from the study had a history with keratoconus or were current wearers of rigid contact lenses.
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