Core-shell hollow spheres of type C@MoS for use in surface-assisted laser desorption/ionization time of flight mass spectrometry of small molecules.

Mesoporous carbon hollow spheres coated with MoS (C@MoS) were synthesized to obtain a material with large specific surface area, fast electron transfer efficiency and good water dispersibility. The composite material was applied as a matrix for the analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). The use of a core-shell C@MoS matrix strongly reduces matrix background interferences and increases signal intensity in the analysis of sulfonamides antibiotics (SAs), cationic dyes, emodin, as well as estrogen and amino acids. The composite material was applied to the SALDI-TOF MS analysis of selected molecules in (spiked) real samples. The ionization mechanism of the core-shell C@MoS as a matrix is discussed. The method exhibits low fragmentation interference, excellent ionization efficiency, high reproducibility and satisfactory salt tolerance. Graphical abstractSchematic representation of the method for fabrication of MoS-coated mesoporous carbon hollow spheres (core-shell C@MoS). As a new matrix, the nanocomposites were applied to analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry.