Despite ongoing advances in the treatment of patients with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS), they remain a major global public health concern conferring an increased risk of morbidity and mortality in affected individuals. This is, in part, because of the widespread dysfunction imposed by HIV and its treatment on the cardiovascular system, including the myocardium, valvular apparatus, pericardium and coronary, pulmonary and peripheral vasculature. In recent times, cardiovascular magnetic resonance (CMR) imaging has emerged as the gold standard tool for assessment of a variety of indications, allowing comprehensive characterisation of functional, morphological, metabolic and haemodynamic sequelae of several cardiovascular pathologies. Furthermore, continued advancement in imaging techniques has yielded novel insights into the underlying pathophysiology and guides future therapeutic strategies. In this article, we review the various clinical phenotypes of HIV-associated cardiovascular disease and highlight the utility of CMR in their assessment.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837809PMC
http://dx.doi.org/10.4102/sajr.v21i2.1248DOI Listing

Publication Analysis

Top Keywords

cardiovascular magnetic
8
magnetic resonance
8
human immunodeficiency
8
cardiovascular disease
8
cardiovascular
5
review cardiovascular
4
resonance human
4
immunodeficiency virus-associated
4
virus-associated cardiovascular
4
disease despite
4

Similar Publications

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

Clinic of Cardiovascular Diseases named after Most Holy John Tobolsky, Moscow, Moscow, Russia.

Background: Dementia aggravates most cerebrovascular lesions, which requires differentiating the developed microcirculatory changes when making a diagnosis. We consider the features of cerebral microcirculation disorders in Alzheimer's disease (AD), distal cerebral atherosclerosis, Binswanger's disease (BD), and vascular parkinsonism (VP).

Method: The study included 1024 patients who underwent: assessment of CDR, TDR, MMSE, cerebral MRI, MRA, CT, MSCTA, scintigraphy (SG), rheoencephalography (REG), cerebral multi-gated angiography (MUGA).

View Article and Find Full Text PDF

Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

Background: Small vessel disease (SVD) is a disorder of the brain's microvessels and a common cause of dementia and stroke. Evidence links normal ageing features to SVD progression, involving endothelial activation, pericyte dysfunction, BBB failure, and microglia response. Here, we aim to examine this relationship through a series of translational investigations.

View Article and Find Full Text PDF

Background: Understanding the neuronal mechanisms of learning and memory is one of the major goals in neurophysiology and neuropsychology. Disorders related to memory consolidation are often the consequences of dynamic plasticity changes, which may lead to a reduction in spine number and density, impairing neural networks. Sleep is one of the major physiological prerequisites for memory consolidation, especially during NREM sleepwhen glymphatic system clearance takes place, too.

View Article and Find Full Text PDF

Background: Dysregulation of cholesterol metabolism contributes to the increase of cerebral vascular diseases, favoring the development of dementia. In this sense, high levels of high-density lipoprotein (HDL) are considered protective against the outcomes associated with cardiovascular diseases. However, little is known about the effect of plasma HDL levels to alterations of cerebral volume in non-vascular AD and vascular AD individuals.

View Article and Find Full Text PDF

Background: Impaired interstitial fluid drainage in the brain is indicated by the presence of perivascular β-amyloid (Aβ) deposits and is attributed to alterations in contractility and relaxation of vascular smooth muscle cells (SMCs). The brain microvasculature in Alzheimer disease (AD) accumulates amyloid-forming amylin secreted from the pancreas. Here, we tested the hypothesis that cerebrovascular amylin deposits perturbs cerebral Aβ efflux by impairing cerebral vasodilation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!