The FP7 project 'Human Cystic Echinococcosis ReseArch in CentraL and Eastern Societies' (HERACLES), developed between 2013 and 2018 by nine partners in five countries, is one of the largest projects on cystic echinococcosis. Here we present the core HERACLES achievements, which should help to foster the translation of scientific investigations on health policies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pt.2019.10.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the mechanism and drug candidates of alveolar echinococcosis affecting liver fibrosis through analysis of existing microarray data.
Acta Trop
January 2025
Department of Department of Anesthesiology, the First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinshi District, Urumqi, Xinjiang, 830054, China; Xinjiang Perioperative Organ Protection Laboratory, No. 137, South Liyushan Road, Xinshi District, Urumqi, Xinjiang, 830054, China. Electronic address:
Echinococcosis, a zoonotic disease, significantly impacts the liver, with alveolar echinococcosis (AE) often leading to liver fibrosis and, in severe cases, cirrhosis. However, the molecular mechanisms by which AE infection promotes liver fibrosis remain incompletely understood. This study utilized bioinformatic analysis of existing microarray data to explore the shared mechanisms between AE and liver fibrosis and to identify potential therapeutic drug candidates.
View Article and Find Full Text PDFEstablishment of Recombinant Gene Rabies Virus SRV and Identification of Its Biological Characteristics.
Viruses
December 2024
School of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830052, China.
Canids act as a crucial intermediary in the transmission of rabies and , serving as co-infection hosts and pathogen carriers for both rabies and hydatid disease (HD) transmitted from animals to humans. Therefore, an effective and efficient bivalent oral vaccine for preventing HD and rabies is urgently required to reduce economic losses in husbandry resulting from rabies and HD. In this study, a full-length plasmid (pcDNA4-NPM+G+EgM123+eGFP+L) carrying the gene and fluorescence reporter genes of eGFP and four auxiliary transfection plasmids of rabies virus SRV (pcDNA4-N, pcDNA4-P, pcDNA4-G, pcDNA-L) were established by reverse genetics approaches and co-transfected to BSR cells by electrotransfection.
View Article and Find Full Text PDFA Comprehensive Analysis of Infections in Children and Adolescents: Results of a 7-Year Retrospective Study and Literature Review.
Pathogens
January 2025
Department of Microbiology and Immunology, Faculty of Pharmacy, "Ovidius" University of Constanta, Str. Căpitan Aviator Al. Șerbănescu, nr.6, Campus Corp C, 900470 Constanta, Romania.
Cystic echinococcosis (CE) is a neglected tropical parasitic disease linked with significant social and economic burdens worldwide. The scientific community has minimal information on echinococcosis in Romanian people, and hospital medical records are the only sources that may be used to investigate its status. A 7-year retrospective clinical study on pediatric patients with CE from Southeast Romania was performed, and 39 children and adolescents were included, aged 2-15 years old.
View Article and Find Full Text PDFRisk factors and economic losses associated with cystic echinococcosis among livestock in selected pastoral and agro-pastoral areas of Uganda.
BMC Vet Res
January 2025
College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda.
Background: Cystic echinococcosis is a parasitic cyclo-zoonotic disease caused by the taeniid Echinococcus and causes significant economic losses in livestock production, yet its impact is often overlooked and under estimated.
Methods: This study investigated the risk factors and economic impact of cystic echinococcosis in livestock, in Uganda's pastoral and agro-pastoral communities. In the study, 14,937 livestock were examined at selected slaughterhouses in Moroto, Kumi, Luwero and Nakasongola districts from March 2019 to February 2020.
Primary hydatid cyst in the axillary region: A case report.
Int J Surg Case Rep
January 2025
Department of General Surgery, Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Introduction: Hydatid disease, caused by the larval stage of Echinococcus granulosus, is a significant zoonotic infection predominantly affecting the liver and lungs. While hydatid cysts are commonly found in internal organs, cases in the axillary region are rare.
Presentation Of Case: We report a unique case of a 52-year-old female patient presenting with a painless left axillary swelling for two years.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!